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Biochemistry I- (2nd Semester)

[ 1st Year ]
LECTURERS: Demetres D. Leonidas, Anna Maria Psarra, Kalliope Liadaki
CONTENT - Aim of the course

Biochemistry studies the chemical reactions occurring in living organisms and therefore can be characterized as "the chemistry of living matter." Biochemistry is the science which deals with the study of all biological processes at the molecular level and includes the sciences of molecular biology, immunochemistry, neurochemistry and Bioinorganic, Bioorganic and Biophysics chemistry. After the decoding the human genome as well as the genome of other organisms, biochemistry has become a scientific field with rapid development. In recent years the research topic of biochemistry has shifted from the level of DNA at the level of proteins to understand their role and elucidate the molecular basis of fundamental processes of organizations such as controlling the growth, development, metabolism and reproduction. Today the applications of biochemistry in health, food and environment are numerous and have many effects on everyday life. The aim of this course is to introduce the students to Biochemistry and its elementary concepts like macromolecule structure and their interactions, introduction to enzymology and the biological role of enzymes, the flow of the genetic information and the major role of nucleic acids and the role of the biological membranes. In addition, the students are introduced to the major pathways of intermediate metabolism and its regulation (Glycolysis, Krebs cycle, Gluconeogenesis, Oxidative phosphorylation, Pentose phosphate pathway).

ANALYTICAL DESCRIPTION OF THE COURSE
  • INTRODUCTION – BIOCHEMICAL EVOLUTION.
  • PROTEIN STRUCTURE AND FUNCTION.
  • ANALYTICAL METHODS TO STUDY PROTEINS.
  • DNA – RNA GENETIC FLOW OF INFORMATION.
  • EXPLORING THE GENES – RECOMBINANT DNA.
  • ENZYMES – BASIC CONCEPTS AND KINETICS.
  • CATALYTIC AND REGULATION STRATEGIES OF ENZYMES.
  • LIPIDS, BIOLOGICAL MEMBRANES, CARBOHYDRATES.
  • INTRODUCTION TO METABOLISM-ATP AS FREE ENERGY COIN-SIGNAL TRANSDUCTION.
  • CARBOHYDRATES METABOLISM-GLYCOLYSIS.
  • KREBS CYCLE.
  • BIOLOGICAL OXIDATIONS-OXIDATIVE PHOSPHORYLATION.
  • GLUCONEOGENESIS-PENTOSE PHOSPHATE PATHWAY.
  • GLYCOGEN METABOLISM.
Practicals
  1. Proteins-Myosin.
  2. Enzyme kinetics.
  3. Carbohydrates.
  4. Oxidative phosphorylation.
  5. Metabolism of liver glycogen.
  6. Metabolism of muscle glycogen. 
ASSESSMENT

The final grade consists of 80% from the final examination at the end of the semester and 20% from the lab practice.

READING SUGGESTIONS
  • Biochemistry (Vol. Ι), Stryer L., 3rd eds, University of Crete Press, 1994 (Greek version).
  • Biochemistry, Berg J.M., Tymoczko J.L., Stryer L., 5th edition, W.H. Freeman and Co., New York, 2002.
 TEACHING MATERIAL / E-class

 http://eclass.uth.gr/eclass/SEYC118

 

Biochemistry studies the chemical reactions occurring in living organisms and therefore can be characterized as "the chemistry of living matter." Biochemistry is the science which deals with the study of all biological processes at the molecular level and includes the sciences of molecular biology, immunochemistry, neurochemistry and Bioinorganic, Bioorganic and Biophysics chemistry. After the decoding the human genome as well as the genome of other organisms, biochemistry has become a scientific field with rapid development. In recent years the research topic of biochemistry has shifted from the level of DNA at the level of proteins to understand their role and elucidate the molecular basis of fundamental processes of organizations such as controlling the growth, development, metabolism and reproduction. Today the applications of biochemistry in health, food and environment are numerous and have many effects on everyday life. The aim of this course is to introduce the students to Biochemistry and its elementary concepts like macromolecule structure and their interactions, introduction to enzymology and the biological role of enzymes, the flow of the genetic information and the major role of nucleic acids and the role of the biological membranes. In addition, the students are introduced to the major pathways of intermediate metabolism and its regulation (Glycolysis, Krebs cycle, Gluconeogenesis, Oxidative phosphorylation, Pentose phosphate pathway).

 

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