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Principles of Molecular Virology - (8th Semester)

[ 4th Year ]
LECTURER : Panayotis Markoulatos, Tilemachos Dimitriou
CONTENT – Aim of the course

The aim of the course is to introduce fundamental principles and current trends in the field of molecular Virology. The course explores and explains the main aspects of virology, including structure of virus particles and genome, replication, transcription, gene expression infection and finally pathogenesis providing a good starting point to rapidly acquire the necessary knowledge of a continuously expanding area.

ANALYTICAL DESCRITION OF THE COURSE
  • Introduction (History of virology .Living host systems .Cell culture methods).
  • Particles (Capsid symmetry and virus architecture. Enveloped viruses. Protein – Nucleic acid interactions and genome packaging. Virus receptors-recognition and binding).
  • Genomes: The structure and complexity of virus genomes. Virus genetics, virus mutants. “Large” and “Small” DNA genomes. Positive strand-Strand RNA viruses. Negative strand- RNA viruses. Segmented and multipartite virus genomes. Reverse Transcription and Transposition.
  • Replication: Overview of virus replication. The replication cycle.
  • Expression: Expression of genetic information. Genome coding strategies. Transcriptional control of expression. Post- Transcriptional control of expression.
  • Infection: Immune responses to virus infections in animals. The course of virus infections.
  • Pathogenesis: Mechanism of cellular injury. Viruses and Immunodeficiency. Virus–related diseases. Cell transformation by viruses. Viruses and cancer .New and emergent viruses.
  • Subviral Agents: Satellites and Viroids. Prions.
 
ASSESSMENT

Student performance is evaluated from the final written examination and from the successful completion of a personal assignment.

READING SUGGESTIONS
  • Principles of Molecular Virology, Alan J. Cann, Elsevier Academic Press, 2005.
  • Fundamentals of Molecular Virology, Nicholas H. Acheson, John Wiley & Sons, 2001.
  • Σημειώσεις Μοριακής Ιολογίας. Π. Μαρκουλάτος. Πανεπιστημιακές Εκδόσεις Πανεπιστημίου Θεσσαλίας, 2008. 

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