Language:

  • Greek
  • English (United Kingdom)

BIOORGANIC CHEMISTRY

         Selections
1. Brief Description 6. Thesis
2. Research Interests 7. Photos
3. Personnel 8. Useful links
4. Funded Research Projects 9. Contact
5. Publications    

1. Brief Description:

The Laboratory of Organic Chemistry (LBC) was established in 2003 and mainly focuses on the synthesis of modified nucleosides and glucosides with interesting anticancer, antiviral, antioxidant and antidiabetic properties. Recently, the research interest also includes the synthesis of modified pyrrolo and quinoxaline analogs possessing interesting pharmaceutical applications.

2. Research Interests:

The research interests of the LBC mainly focus on the synthesis of novel modified nucleoside analogues with interesting properties and biological activities.

Modified nucleosides play an important role in antiviral and anticancer chemotherapy. It is noteworthy that 15% of anticancer agents and 55% of antiviral agents are related to nucleoside analogues. The last decades nucleosides with five-membered and six-membered carbohydrate moieties have been evaluated for their potential antiviral and anticancer properties and as building blocks in nucleic acid chemistry. Lately, considerable interest in, exomethylene, fluoro and fluorothionucleosides has been generated in order to find new antitumor, antiviral, or anti-HIV drugs with better selectivity and less immunosuppressive effects compared with known clinically used compounds. It is also noteworthy that unsaturated ketonucleosides have been established for their antineoplastic activity and immunosuppressive effects. Based on these considerations the research interest of the LBC mainly focuses on the synthesis and biological evaluation of novel nucleoside analogues with specific structural features in the sugar and base moieties, such as unsaturation, exomethylene, fluorine, sulfur, cyano and ethynyl functions.

Pyrrole ring has found a wide number of applications and is present in many natural products. It is used as an important skeleton in organic synthesis and is also utilized in other important fields, such as materials science, medicinal chemistry, and pharmacology. Especially, 2-oxopyrroles show versatility and they are important substructures in a variety of drugs, including products active against viral infections (HIV , influenza, cytomegalovirus), anticancer agents, and products active against microbiological diseases (bacterial or fungal). Pyrroles fused to other heterocyclic systems, such as quinoxalines, have been of particular interest, since quinoxaline derivatives constitute the basis of many insecticides, fungicides, herbicides, as well as being important in human health and as receptor antagonists. Based on these data, the research in the LBC also includes the synthesis of halogenated pyrroles and their corresponding quinoxaline analogues.

3. Personnel:

  •  Professor of Bio-Organic Chemistry  Dimitris Komiotis
  • Senior Teaching Staff Christos Mitsos
  • Senior Researcher Nliki Tzioumaki

 

PhD Candidates

  •  Nikolaos Kollatos

4. Funded Research Programs:

1. Research of Chemical Compounds against AIDS Title: 'Μodified Ιsoniazids Αgainst AIDS'. Funding Body: American Institute of Health. Duration: 1990 – 1993. Coordinator: D.L. Venton.

2. oint Research Program Greece – Slovenia, Title: 'Synthesis and biological evaluation of a new class of amino-fluoronucleosides with potential antiviral and anticancer activity'. Funding Body: General Secretariat for Research and Technology. Duration: 2004 – 2006. Coordinator: D. Komiotis.

3. Research Program Pythagoras ΙΙ, Title: 'Molecular Detection of enteroviruses in clinical samples and environment. Consequences in public health. Funding Body: European Union, European Committee, European Social Fund. Duration: 2005 – 2008. Coordinator: P. Markoulatos.

4. Joint Research Program Greece – France Title: 'Human Angiogenine as molecular target of developing anticancer agents΄. Funding Body: General Secretariat for Research and Technology. Duration: 2010 – 2012. Coordinator: D. Leonidas.

5. Research Program Aristeia I. Title: 'Structure-assisted Design, Synthesis, and Evaluation of Bioactive compounds for type 2 Diabetes mellitus'. Funding Body: General Secretariat for Research and Technology. Duration: 2012 – 2015. Coordinator: D. Komiotis.

6. Focused Research Action. Title: 'Pyranosyl-amide as novel therapeutic agents for the treatment of type 2 Diabetes mellitus' Funding Body: Research Committee University of Thessaly. Duration: 2012 – 2013.

7. Education and Lifelong Learning - Updating Graduate Knowledge. Title: "Medicine, Pharmacy, Biotechnology": "Modern Bio-Analysis Techniques in Health, Environment and Nutrition". Duration: 2014 –2016.

   5.  Publications:

  • New short route to unsaturated fluoroketonucleosides: Case of 5-fluoro-1-(6-O-acetyl-3,4-dideoxy-3-fluoro-β-D-glycero-hex-3-eno-pyranos-2-ulosyl)uracil. Marie Jose Egron, Dimitri Komiotis, Ismet Dorange, Jean Herscovici and Kostas Antonakis. Nucleosides Nucleotides and Nucleic Acids, 24, (2005), 243-246.
  • A facile, one step, conversion of O-Trityl and O-TBDMS sugars into corresponding formate esters. Dimitri Komiotis, George Agelis, Stella Manta, Niki Tzioumaki, Evangelia Tsoukala and Kostas Antonakis. J. Carbohydr. Chem., 25, (2006), 441-450.
  • Detection of unusual mutation within the VP1 region of different re-isolates of poliovirus Sabin vaccine. Evaggelos Dedepsidis, Ioannis Karakasiliotis, Eleni Paximadi, Zaharoula Kyriakopoulou, Dimitri Komiotis and Panayotis Markoulatos. Virus Genes, 33, (2006), 183-191.
  • Fluoro-ketopyranosyl nucleosides: Synthesis and biological evaluation of 3-fluoro-2-keto-β-D-glucopyranosyl derivatives of N4-benzoyl cytosine. Stella Manta, George Agelis, Tanja Botić, Avrelija Cencič and Dimitri Komiotis. Bioorg. Med. Chem., 15, (2007), 980 – 987.
  • An efficient synthesis of 3-fluoro-5-thio-β-D-xylofuranosyl nucleosides of thymine, uracil and 5-fluorouracil as Potential Antitumor or/and Antiviral Agents. Evangelia Tsoukala, George Agelis, Jan Dolinšek, Tanja Botić, Avrelija Cencič and Dimitri Komiotis. Bioorg. Med. Chem., 15, (2007), 3241 – 3247.
  • Synthesis and structural characterization of neutral “3+2” οxorhenium and οxotechnetium complexes of the 2-mercaptoethyl-N-glycine (SNO) / 2,2΄-bipyridine (NN) mixed ligand system. Dionysia Papagiannopoulou, Ioannis Pirmettis, Maria Pelecanou, Dimitri Komiotis, Catherine P. Raptopoulou, Aris Terzis, Minas S. Papadopoulos. Inorg. Chim. Acta., 360, (2007), 3597-3602.
  • Exomethylene pyranonucleosides: Efficient synthesis and biological evaluation of 1-(2,3,4-trideoxy-2-methylene-β-D-glycero-hex-3-enopyranosyl)thymine. George Agelis, Niki Tzioumaki, Jan Dolinšek, Tanja Botić, Avrelija Cencič and Dimitri Komiotis. Bioorg. Med. Chem., 15, (2007), 5448 - 5456.
  • Antioxidant activity of a series of fluorinated pyrano-nucleoside analogues of N4-benzoyl cytosine and N6-benzoyl adenine. Chrysoula Spanou, Stella Manta, Dimitri Komiotis and Demetrios Kouretas. Int. J. Mol. Sci., 8, (2007), 695 - 704.
  • A Retrospective characterization of a Vaccine derived Poliovirus type 1 isolated from sewages in Greece. Evaggelos Dedepsidis, Zaharoula Kyriakopoulou, Vaia Pliaka, Christine Kottaridi, Eugenia Bolanaki, Stamatina Levidiotou-Stefanou, Dimitri Komiotis and Panayotis Markoulatos. Appl. Environ. Microbiol., 73, (2007), 6697 - 6704.
  • Unsaturated fluoro-ketopyranosyl nucleosides: Synthesis and biological evaluation of 3-fluoro-4-keto-β-D-glucopyranosyl derivatives of N4-benjoyl cytosine and N6-benzoyl adenine. Stella Manta, George Agelis, Tanja Botić, Avrelija Cencič and Dimitri Komiotis. Eur. J. Med. Chem., 43, (2008), 420 – 428.
  • A concise synthesis of 3-fluoro-5-thio-xylo- and glucopyranoses, useful precursors towards their corresponding pyranonucleoside derivatives. Evangelia Tsoukala, Stella Manta, Niki Tzioumaki, George Agelis and Dimitri Komiotis. Carbohydr. Res., 343, (2008), 1099 – 1103.
  • Exomethylene pyranonucleosides: Synthesis, conformational analysis and biological evaluation of 1-(2,3,4-trideoxy-4-methylene-α-D-glycero-hex-2-enopyranosyl)uracile. George Agelis, Niki Tzioumaki, Theodore Tselios, Jan Dolinšek, Tanja Botić, Avrelija Cencič and Dimitri Komiotis. Eur. J.  Med. Chem., 43, (2008), 1366 – 1375.
  • Antioxidant and chemopreventive properties of Polyphenolic compound derived from Greek legume plant extracts. Chrisoula Spanou, Georgia Bourou, Albiona Dervishi, Nektarios Aligiannis, Apostolos Angelis, Dimitri Komiotis, Alexios-Leandros Skaltsounis and Demetrios Kouretas. J. Agric. Food Chem., 56, (2008), 6967 – 6976.
  • Antiviral Unsaturated Nucleosides. Dimitri Komiotis, Stella Manta, Evangelia Tsoukala, and Niki Tzioumaki. Curr. Med. Chem., 7, (2008), 219 - 244.
  • Competitive Inhibition of Human Poly(A)-Specific Ribonuclease (PARN) by Synthetic Fluoro-Pyranosyl Nucleosides. Nikolaos Balatsos, Dimitrios Vlachakis, Panagiotis Maragozidis, Stella Manta, Dimitrios Anastasakis, Athanasios Kyritsis, Metaxia Vlassi, Dimitri Komiotis and Constantinos Stathopoulos. Biochemistry, 48, (2009), 6044-6051.
  • Synthesis, Antiviral and Cytostatic Evaluation of Unsaturated Exomethylene & Keto D-Lyxopyranonucleoside Analogues. Niki Tzioumaki, Evangelia Tsoukala, Stella Manta, George Agelis, Jan Balzarini and Dimitri Komiotis. Archiv der Pharmazie, 342, (2009), 353-360.
  • Dideoxy fluoro-ketopyranosyl nucleosides as potent antiviral agents: Synthesis and biological evaluation of 2,3- and 3,4-dideoxy-3-fluoro 4- and -2-keto-β-D-glucopyranosyl derivatives of N4-benzoyl cytosine. Stella Manta, Evangelia Tsoukala, Ales Goropevšek, Ravi Teja Pamulapati, Avrelija Cencič, Jan Balzarini and Dimitri Komiotis. Eur. J. Med. Chem. 44, (2009), 2696-2704.
  • Unsaturated dideoxy fluoro-ketopyranosyl nucleosides as potent antitumor agents: A convenient synthesis of 2,6-dideoxy-3-fluoro-4-keto-β-D-glucopyranosyl analogues of uracil, 5-fluorouracil, thymine, N4-benzoyl cytosine and N6-benzoyl adenine. Stella Manta, Niki Tzioumaki, Evangelia Tsoukala, Aggeliki Panagiotopoulou, Maria Pelecanou, Jan Balzarini and Dimitri Komiotis. Eur. J. Med. Chem. 44, (2009), 4764–4771.
  • Fluoro-glucopyranosyl derivatives of Ketonucleosides, potent inhibitors of DNA virus replication in infected cells. Tanja Botic, Stella Manta, Dimitri Komiotis, Avrelija Cencič and Francois Lefevre. Acta Medico-Biotechnica 2, (2009), 41-47.
  • Synthesis of 4,6-dideoxy-3-fluoro-2-keto-β-D-glucopyranosyl analogues of 5-fluorouracil, N6-benzoyl adenine, uracil, thymine and N6-benzoyl cytosine and evaluation of their antitumor activities. Stella Manta, Evangelia Tsoukala, Niki Tzioumaki, Christos Kiritsis, Jan Balzarini and Dimitri Komiotis. Bioorg. Chem. 38, (2010), 48-55.
  • Fluoro-glucopyranosyl derivatives of Ketonucleosides, potent inhibitors of DNA virus replication in infected cells. Tanja Botic, Stella Manta, Dimitri Komiotis, Avrelija Cencič and Francois Lefevre. Acta Medico-Biotechnica 2, (2009), 41-47.
  • 1-(3-Deoxy-3-fluoro-β-D-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: kinetic, crystallographic and modelling studies. Vicky G. Tsirkone, Evangelia Tsoukala, Christos Lamprakis, Stella Manta, Joseph M. Hayes, Vicky T. Skamnaki, Christina Drakou, Spyros E. Zographos, Dimitri Komiotis and Demetres D. Leonidas. Bioorg. Med. Chem. 18, (2010) 3413-3425.
  • Synthesis of 3-fluoro-6-S-(2-S-pyridyl) nucleosides as potential lead cytostatic agents. Evangelia Tsoukala, Niki Tzioumaki, Stella Manta, Alexandra Riga, Jan Balzarini and Dimitri Komiotis. Bioorganic Chemistry 38, (2010), 285-293.
  • Efficient Synthesis of Exomethylene- & Keto-Exomethylene-D-Glucopyranosyl Nucleoside Analogs as Potential Cytotoxic Agents. Niki Tzioumaki, Evangelia Tsoukala, Stella Manta, Christos Kiritsis, Jan Balzarini, and Dimitri Komiotis. Carbohydrate Research 346, (2011), 328-333.
  • Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogues: Novel 5-fluorouracil analogues that target thymidylate synthase. Niki Tzioumaki, Stella Manta, Evangelia Tsoukala, Johan Vande Voorde, Sandra Liekens, Dimitri Komiotis and Jan Balzarini. Eur. J. Med. Chem., 46, (2011), 993-1005.
  • Keto-fluorothiopyranosyl nucleosides: A convenient synthesis of 2- and 4-keto- 3-fluoro-5-thioxylopyranosyl thymine analogs. Evangelia Tsoukala, Stella Manta, Niki Tzioumaki, Christos Kiritsis and Dimitri Komiotis. Carbohydrate Research 346, (2011), 2011-2015.
  • Unsaturated Keto and Exomethylene Pyranonucleoside Analogues of Thymine and Uracil Exhibit Potent Antioxidant Properties. Chrysoula Spanou, Niki Tzioumaki, Stella Manta, Panagiotis Margaris, Dimitrios Kouretas, Dimitri Komiotis, Kalliopi Liadaki. Pharmacology & Pharmacy 2, (2011), 122-126.
  • Branched-chain C-cyano pyranonucleosides: Synthesis of 3΄-C-cyano & 3΄-C-cyano-3΄-deoxy pyrimidine pyranonucleosides as novel cytotoxic agents. Christos Kiritsis, Stella Manta, Vanessa Parmenopoulou, Jan Balzarini and Dimitri Komiotis. Eur. J. Med. Chem., 46, (2011), 5668-5674.
  • Kinetic and in silico analysis of the effective slow-binding inhibition of human Poly(A)-Specific Ribonuclease (PARN) by drastic nucleoside analogues. Nikolaos Balatsos, Dimitrios Vlachakis, Vassiliki Chatzigeorgiou, Stella Manta, Dimitri Komiotis, Metaxia Vlassi and Constantinos Stathopoulos. Biochimie 94, (2012), 214-221.
  • Keto and Exomethylene Pyranonucleosides as Antitumor Agents. Evangelia Tsoukala, Stella Manta, Christos Kiritsis and Dimitri Komiotis. Mini Rev. Med. Chem. 12, (2012), 255-275.
  • 3′-Axial CH2OH Substitution on Glucopyranose does not Increase Glycogen Phosphorylase Inhibitory Potency. QM/MM-PBSA Calculations Suggest Why. S. Manta, A. Xipnitou, C. Kiritsis, A.L. Kantsadi, J.M. Hayes, V.T. Skamnaki, C. Lamprakis, M. Kontou, P. Zoumpoulakis, S.E. Zographos, D.D. Leonidas, and D. Komiotis. Chem Biol Drug Design, 79, (2012), 663-673.
  • The σ-hole phenomenon of halogen atoms forms the structural basis of the strong inhibitory potency of C-5 halogen substituted glucopyranosyl nucleosides for glycogen phosphorylase b. Anastasia L. Kantsadi, Joseph M. Hayes, Stella Manta, Vicky T. Skamnaki, Christos Kiritsis, Anna-Maria G. Psarra, Zissis Koutsogiannis, Athina Dimopoulou, Stavroula Theofanous, Nikolaos Nikoleousakos, Panagiotis Zoumpoulakis, Maria Kontou, George Papadopoulos, Spyros E. Zographos, Dimitri Komiotis, and Demetres D. Leonidas. ChemMedChem. 4, (2012), 722-732.
  • Synthesis and Biological Evaluation of 3΄-C-Ethynyl and 3΄-C-(1,4-disubstituted-1,2,3-triazolo) Double-Headed Pyranonucleosides. Christos Kiritsis, Stella Manta, Evdoxia Coutouli-Argyropoulou, Sakellarios Trakossas, Jan Balzarini and Dimitri Komiotis. Med. Chem. 8, (2012), 320-329.
  • Stereocontrolled Facile Synthesis And Biological Evaluation of (3΄S) and (3΄R)-3΄-Amino (and azido)-3΄-Deoxy Pyranonucleosides. Stella Manta, Vanessa Parmenopoulou, Christos Kiritsis, Athina Dimopoulou, Nikolaos Kollatos, Jan Balzarini and Dimitri Komiotis. Nucleosides, Nucleotides and Nucleic Acids. 31, (2012), 522-535.
  • The binding of C5-alkynyl and alkylfurano[2,3-d]pyrimidine glucopyranonucleosides to glycogen phosphorylase b. Synthesis, biochemical and biological assessment. Kantsadi, A.L., Manta, S., G. Psarra, A.-M., Dimopoulou, A., Kiritsis, C., Parmenopoulou, V., Skamnaki, V.T., Zoumpoulakis, P., Zographos, S.E., Leonidas, D.D. , Komiotis, D. Eur. J. Med. Chem., 54, (2012), 740-749.
  • Conformational Analysis of two novel cytotoxic C2-substituted pyrrolo[2,3- f]quinolines in aqueous media, organic solvents, membrane bilayers and at the putative active site. N. Varvarigou, G. Megariotis, G. Leonis, E. Vrontaki, A. Maniati, M. Vlachou, A. Eikosipentaki, R. Kompogennitaki, M. G. Papadopoulos, S. Golic Grdadolnik, D. Komiotis, T. Mavromoustakos, A. Tsotinis. Bioorg. Med. Chem. 20, (2012), 6276-6284.
  • Triazole pyrimidine nucleosides as inhibitors of Ribonuclease A. Synthesis, biochemical, and structural evaluation. Vanessa Parmenopoulou, Demetra S Chatzileontiadou, Stella Manta, Stamatina Bougiatioti, Panagiotis Maragozidis, Dimitra-Niki Gkaragkouni, Eleni Kaffesaki, Anastasia L Kantsadi, Vassiliki T Skamnaki, Spyros E Zographos, Nikolaos A. Balatsos, Dimitris Komiotis, Demetres D. Leonidas. Bioorg. Med. Chem. 20, (2012), 7184-7193.
  • An intergraded in silico approach to design specific inhibitors targeting human poly(A)-specific ribonuclease. D. Vlachakis, A. Pavlopoulou, G. Tsiliki, D. Komiotis, C. Stathopoulos, N.A.A. Balatsos and S. Kossida. Plos One 7, (2012), e51113.
  • Stereocontrolled Synthesis of 4΄-C-cyano and 4΄-C-cyano-4΄-deoxy Pyrimidine Pyranonucleosides as Potential Chemotherapeutic Agents. C. Kiritsis, S. Manta, V. Parmenopoulou, A. Dimopoulou, N. Kollatos, I. Papasotiriou, J. Balzarini and D. Komiotis. Carbohydr. Res. 364 (2012), 8-14.
  • Rapid Microwave-Enhanced Synthesis of C5-Alkynyl Pyranonucleosides as Novel Cytotoxic Antitumor Agents. A. Dimopoulou, S. Manta, C. Kiritsis, D.-N. Gkaragkouni, Jan Balzarini and D. Komiotis. Bioorg. Med. Chem. Lett. 23 (2013), 1330-1333.
  • Anvirzel™ in combination with cisplatin in breast, colon, lung, prostate, melanoma and pancreatic cancer cell lines. P. Apostolou, M. Toloudi, M. Chatziioannou, E. Ioannou, D.R. Knocke, J. Nester, D. Komiotis, I. Papasotiriou. BMC Pharmacology & Toxicology (2013), 14:18.
  • Study of the interaction among notch pathway receptors, correlation with stemness, as well as their interaction with cd44, dipeptidyl peptidase-iv, hepatocyte growth factor receptor and the setmar transferase, in colon cancer stem cells. P. Apostolou, M. Toloudi, E. Ioannou, E. Kourtidou, M. Chatziioannou, A. Kopic, D. Komiotis, C. Kiritsis, S. Manta, and I.papasotiriou. J Recept Sig Transd. 33 (2013), 353-358.
  • Stereoselective facile synthesis of 2′-spiro pyrimidine pyranonucleosides via their key intermediate 2′-c-cyano analogues. Evaluation of their bioactivity. C. Kiritsis, s. Manta, a. Dimopoulou, v. Parmenopoulou, p. Gkizis, j. Balzarini, and D. Komiotis. Carbohydr. Res. 383, (2014), 50-57.
  • Unsaturation: An Important Feature to Nucleosides' Antiviral Activity. S. Manta, C. Kiritsis, A. Dimopoulou, V. Parmenopoulou, N.Kollatos, A.Tsotinis and D. Komiotis. Anti- Infective Agents, 12 (2014), 2-57.
  • Comparison of the Growth Curves of Cancer Cells and Cancer Stem Cells. M. Toloudi, E. Ioannou, M. Chatziioannou, P. Apostolou, C.Kiritsis, S. Manta, D. Komiotis, I. Papasotiriou. Curr Stem Cell Res Ther. 9(2014), 112-16.
  • A novel and easy two-step microwave-assisted method for the synthesis of halogenophenyl pyrrolo[2,3-b]quinoxalines via their pyrrolo precursors. Evaluation of their bioactivity.' S. Manta, D.N. Gkaragkouni, E. Kaffesaki, P. Gkizis, D. Hadjipavlou- Litina, E. Pontiki, J. Balzarini, W. Dehaen and D. Komiotis, Tet. Lett. 56 (2014), 1873- 76.
  • Structure based inhibitor design targeting glycogen phosphorylase b. Virtual screening, synthesis, biochemical and biological assessment of novel N–(β-D-glucopyranosyl) amides. V.Parmenopoulou, A. L. Kantsadia, V. G. Tsirkonea, D. S.M. Chatzileontiadou, S. Manta, S. E. Zographos, N. Kollatos, G.Archontis, L. Agiuse, J. M. Hayes, D.D. Leonidas and D. Komiotis, Biorg. Med. Chem. 22 (2014), 4810-25.
  • Duplex Real-time PCR assay and SYBR green I melting curve analysis for molecular identification of HPV genotypes 16, 18, 31, 35, 51 and 66. D. Tsakogiannis, M. Papacharalampous, E. Toska, Z. Kyriakopoulou, T.G. Dimitriou, I.G.A. Ruether, D. Komiotis, P. Markoulatos. Molecular and Cellular Probes 29 (2015), 13-18.
  • Synthesis of novel thiopurine pyranonucleosides: Evaluation of their bioactivity. Athina Dimopoulou, Stella Manta, Vanessa Parmenopoulou, Petros Gkizis, Evdoxia Coutouli-Argyropoulou,b Dominique Schols,c and Dimitri Komiotis. Nucleosides Nucleotides and Nucleic Acids (2015), 289-297.
  • Branched-chain sugar nucleosides: Stereocontrolled synthesis and bioevaluation of novel 3΄-C-trifluoromethyl and 3΄-C-methyl pyranonucleosides. Nikolaos Kollatos, Stella Manta, Athina Dimopoulou, Vanessa Parmenopoulou, Virginia V. Triantakonstanti,Tahsin Kellici, Thomas Mavromoustakosc, Dominique Schols, Dimitri Komiotis. Carbohydr. Res. 407 (2015), 170-178.
  • An easy microwave-assisted synthesis of C8-alkynyl adenine pyranonucleosides as novel cytotoxic antitumor agents. Athina Dimopoulou, Stella Manta, Vanessa Parmenopoulou, Nikolaos Kollatos, Ourania Christidou, VirginiaTriantakonstanti, Dominique Schols and Dimitri Komiotis. Frontiers in Chemistry, Medicinal and Pharmaceutical Chemistry section, 3 (2015), 1-7.
  • Dissipation, metabolism and sorption of pesticides used in fruit-packaging plants: Towards an optimized depuration of their pesticide-contaminated agro-industrial effluents. Panagiotis Karas, Aria Metsoviti, Vasileios Zisis, Constantinos Ehaliotis, Michalis Omirou, Evangelia S. Papadopoulou, Urania Menkissoglou-Spiroudi, Stella Manta, Dimitri Komiotis, Dimitrios G. Karpouzas. Science of The Total Environment, 530-31 (2015), 129-139.
  • Glycogen Phosphorylase as a Target for Type 2 Diabetes: Synthetic, Biochemical, Structural and Computational Evaluation of Novel N-acyl-N´-(β-D-glucopyranosyl) Urea Inhibitors. Anastassia L. Kantsadi, Vanessa Parmenopoulou, Dimitar N. Bakalov, Laura Snelgrove, George A. Stravodimos, Demetra S.M. Chatzileontiadou, Stella Manta, Angeliki Panagiotopoulou, Joseph M. Hayes, Dimitri Komiotis, Demetres D. Leonidas. Curr. Topics Med. Chem. 15 (2015), 2373-2389.
  • Triazole double-headed ribonucleosides as inhibitors of eosinophil derived neurotoxin. Demetra S.M Chatzileontiadou, Vanessa Parmenopoulou, Stella Manta, Anastassia L. Kantsadi, Paroula Kylindri, Marianna Griniezaki, Filitsa Kontopoulou, Aikaterini Telopoulou, Helena Prokova, Dimitrios Panagopoulos, Ester Boix, Nikolaos A.A Balatsos, Dimitri Komiotis, Demetres D. Leonidas. Bioorg. Chem. 63 (2015), 152-165.
  • Synthesis of novel N-acyl-β-D-glucopyranosylamines and ureas as potential lead cytostatic agents. Vanessa Parmenopoulou, Stella Manta, Athina Dimopoulou, Nikolaos Kollatos, Dominique Schols, Dimitri Komiotis. Med, Chem. Res. 25 (2016), 932-940.
  • Novel feed including bioactive compounds from winery wastes improved broilers' redox status in blood and tissues of vital organs. Sotiria Makri, Ioannis Kafantaris, Dimitrios Stagos, Theodora Chamokeridou, Konstantinos Petrotos , Konstantinos Gerasopoulos, Anastasios Mpesios, Nikolaos Goutzourelas, Stylianos Kokkas, Panagiotis Goulas, Dimitrios Komiotis, Dimitrios Kouretas. Food Chem. Toxicol. 102 (2017), 24-31.
  • Rapid Microwave-Assisted Synthesis of Modified Pyrimidine and Purine Pyranonucleosides as Novel Cytotoxic, Antiviral Agents and Glycogen Phosphorylase B Inhibitors. Manta Stella, Dimopoulou Athina, Kollatos Nikolaos, Kyrkou Georgia, Spanos Stylianos and Komiotis Dimitri. Med. Chem. 7(5) (2017), 865-868.
  • Facile microwave-assisted synthesis of various C5-modified pyrimidine pyranonucleosides as potential cytotoxic antitumor agents. Athina Dimopoulou, Nikolaos Kollatos, Stella Manta, Aggeliki Panagiotopoulou, Athanasios Karastergiou, Filitsa Kontopoulou, Dominique Schols and Dimitri Komiotis. Curr. Microwave Chem. 4(4) (2017), 324-338.
  • Evidence for Novel Action at the CellBinding Site of Human Angiogenin Revealed by Heteronuclear NMR Spectroscopy, in silico and in vivo Studies. Demetra Chatzileontiadou, Aikaterini Tsika, Zoi Diamantopoulou, Jean Delbé, Josette Badet, Jose Courty, Vassiliki Skamnaki, Vanessa Parmenopoulou, Dimitri Komiotis, Joseph Hayes, Georgios Spyroulias, Demetres Leonidas. Chem. Med. Chem. 13(3) (2018), 259-269.
  • Polyfunctionalized Pyrrole Derivatives: Easy Three-component Microwave-assisted Synthesis, Cytostatic and Antiviral Evaluation. Stella Manta, Niki Tzioumaki, Nikolaos Kollatos Pelagia Andrea, Marili Margaritouli, Aggeliki Panagiotopoulou, Ioannis Papanastasiou, Christos Mitsos,  Andrew Tsotinis, Dominique Schols and Dimitri Komiotis. Curr. Microwave Chem. 5(1) (2018), 23-31.
  • Novel Feed Including Olive Oil Mill Wastewater Bioactive Compounds Enhanced the Redox Status of Lambs. Sotiria Makri, Ioannis Kafantaris, Salomi Savva, Polyxeni Ntanou, Dimitrios Stagos, Ioannis Argyroulis, Basiliki Kotsampasi, Vladimiros Christodoulou, Konstantinos Gerasopoulos, Konstantinos Petrotos, Dimitrios Komiotis and Demetrios Kouretas. in vivo, 32 (2018), 291-302.
  • Synthesis of diphenoxyadamantane alkylamines with pharmacological interest. Markos-Orestis Georgiadis, Violeta Kourbeli, Vaya Ioannidou, Evangelos Karakitsios, Ioannis Papanastasiou, Andrew Tsotinis, Dimitri Komiotis, Anthony Vocat, Stewart T.Cole, Martin C.Taylor, John M.Kelly. Bioorg. Med. Chem, Lett. 29(11) (2019), 1278-1281.
  • Design, Synthesis, and Biological Evaluation of Novel C5-Modified Pyrimidine Ribofuranonucleosides as Potential Antitumor or/and Antiviral Agents. Nikolaos Kollatos, Christos Mitsos, Stella Manta, Niki Tzioumaki, Christos Giannakas, Tania Alexouli, Aggeliki Panagiotopoulou, Dominique Schols, Graciela Andrei, Dimitri Komiotis. Med Chem. 2019 Feb 24. doi: 10.2174/1573406415666190225112950.
  • Design, Synthesis, and Biological Evaluation of Novel C5-Modified Pyrimidine Acyclic Nucleosides. Nikolaos Kollatos, Christos Mitsos, Roula Karetsou, Styliani Danai Antonaki, Aggeliki Panagiotopoulou, Niki Tzioumaki, Stella Manta, Dominique Schols and Dimitri Komiotis. Journal of Pharmaceutics and Drug Research, (Accepted)

6. Thesis:

BSc Thesis
  • Karantana Stella (2004) Studies in crystalisation of inulin during gel formation – Applications in Food Industry (Supervisor: D. Komiotis)
  • Manoli Christina (2005) Synthesis of a new class of fluoronucleosides with potential antiviral and anticancer activity (Supervisor: D. Komiotis)
  • Xenitidis Panagiotis (2006) Factorization in place one of glucose for potential complexation with metals migration (Supervisor: D. Komiotis)
  • Tsoukala Evangelia (2006) Synthesis of 1-(3-deoxy-3-fluoro-5-S-acetyl-5-thio-β-D-xylofuranosyl) nucleoside of thymine with potential antiviral and anticancer activity (Supervisor: D. Komiotis)
  • Svirinaki Pelagia (2007) Unsaturated fluoro-ketopyranonucleosides: Synthesis and biological evaluation of  3-fluoro-4-keto-β-D-glucopyranosyl derivatives of N4–benzoylcytosine and of Ν6–benzoyl adenine (Supervisor: D. Komiotis)
  • Tsiggiavouridou Despoina (2007)Synthesis and  biological evaluation of 2΄-keto and 2΄-exomethylene pyranonucleosides of thymine (Supervisor: D. Komiotis)
  • Symeonidi Despoina (2007) Synthesis and  biological evaluation of 3΄-fluoro-6΄-thio-nucleosides of thymine, uracil and 5-fluorouracil (Supervisor: D. Komiotis)
  • Patista Eleonora-Iris (2009) Fluoro-thio-xylo and glucopyranoses: precursors for  the synthesis of new antiviral and anticancer nucleosides (Supervisor: D. Komiotis)
  • Zingou Lenitsa (2009) 4΄,6΄-Dideoxy-2΄-ketounsaturated-3΄-fluoro-β-D-glucopyranonucleosides of Ν6-benzoyl adenine and of Ν4-benzoyl cytosine: Synthesis and  biological evaluation (Supervisor: D. Komiotis)
  • Petrakis Tsampikos (2010) Synthesis of unsaturated dideoxy fluoro-ketopyranonucleosides of cytosine and of adenine as new anticancer agents (Supervisor: D. Komiotis)
  • Elefteriadou Ioanna (2010) Synthesis of 4-κετοunsaturated-3-fluor-5-sulfur-xylopyranonucleoside of thymine (Supervisor: D. Komiotis)
  • Kontopoulou Stergiani-Paraskevi (2012) Synthesis of new 4΄-deoxy-4΄-C-cyanonucleosides with potential antiviral and anticancer activity (Supervisor: D. Komiotis)
  • Svetzouri Kyriaki (2012) Synthesis of new triazole ribofuranonucleosides as inhibitors of RNAse A (Supervisor: D. Komiotis)
  • Lazaridou Ioanna (2012) Synthesis of new 2-keto-3-exomethylene pzranonucleosides as new antiviral and anticancer agents (Supervisor: D. Komiotis)
  • Stathi Georgia (2012) Synthesis of new triazole ribofuranonucleosides of uracil and thymine as potential anticancer agents (Supervisor: D. Komiotis)
  • Zioga Maria (2012) Synthesis of 1-(3'-azido-3'-deoxy allopyranonucleoside) of 5-fluorouracil as potential antiviral or anticancer agent (Supervisor: D. Komiotis)
  • Marmeloudi Nana (2013) Synthesis of2΄-deoxy-2΄-cyano pyranonucleoside of uracil as potential anticancer agent (Supervisor: D. Komiotis)
  • Geladari Evaggelia (2015) Comparison of conventional and microwave synthesis of pyrrolo-quinoxalines (Supervisor: D. Komiotis)
  • Vaitsopoulou Afroditi (2016) Synthesis of novel pyranonucleosides labeled with 18F for use on molecular imaging and in vivo cancer prediction (Supervisor: D. Komiotis)
  • Christidou Urania (2016) Synthesis and biological evaluation of fluorophenyl pyrroles (Supervisor: D. Komiotis)
  • Paliou Konstantina (2017) New C5 arylalkynyl-3΄-deoxy-ribofuranonuncleosides of uracile as potential antiviral and antitumor agents (Supervisor: D. Komiotis)
  • Georgiou Maria (2017)C5 Halogen phenyl ribofurano nucleosides of uracile as potential cytotoxic and antiviral agents (Supervisor: D. Komiotis)
  • Sergkenli Rosa (2017) New furanonucleosides modified on base. Synthesis and biological evaluation(Supervisor: D. Komiotis)
  • Papamargariti Maria (2018)C5-Arylalcinyl-2'-deoxy-furanonucleosides of uracil as potential antiviral and anticancer agents (Supervisor: D. Komiotis)
  • Miliouli Melanthia (2019) Synthesis and cytotoxic activity of the new modified at the heterocyclic base 3' trifthoromethyl-pyranonucleosides (Supervisor: D. Komiotis)
  • Anagnostopoulos Andreas (2019) Synthesis and spectroscopic characterization of novel alkynyl-substituted quinazoline derivatives as potential anticancer agents.(Supervisor: D. Komiotis)
  • Karetsou Varvara (2019) Synthesis and biological evaluation of base-modified acyclic nucleosides with potential antiviral and anticancer activity (Supervisor: C. Mitsos)
  • Tsilofiti Maria (2019) Comparative study of the synthesis of new modified purine analogs with conventional and microwave heating (Supervisor: C. Mitsos)
  • Liolios Vasilis (2019) Synthesis and biologicalevaluationof new 3΄-trifluoromethylopyrranonucleosides, which are modified in the uracile base (Supervisor: D. Komiotis)

 

MSc Thesis
  • Portesis Nikos (2009) Synthesis of nucleoside analogues of galactose and mannose and study of their antioxidant activity (Supervisor: D. Komiotis
  • Margaris Panagiotis (2009) Synthesis of nucleoside analogues of lyxose and arabinose and study of their  antioxidant activity (Supervisor: D. Komiotis)
  • Riga Alexandra (2010) Synthesis of fluorinated thiopyridinylo nucleoside analogues as potential cytostatic agents (Supervisor: D. Komiotis)
  • Kiritsis Christos (2010) Synthesis of new ethynyl and cyano nucleosides as potential antiviral and anticancer agents (Supervisor: D. Komiotis)
  • Fountarlis Dimitris (2010) Synthesis and potential antioxidant activity of novel keto-exomethylene nucleosides of thymine  (Supervisor: D. Komiotis)
  • Vavilis Theofanis(2010) Synthesis and biological evaluation of ketounsaturated nucleoside of trifluoromethyluracil (Supervisor: D. Komiotis)
  • Kapetanidou Triantafilia (2010) HACCP system application in a hospital unit (Supervisor: D. Komiotis)
  • Kiritsis Christos (2010) Synthesis of new ethynyl and cyanonucleosides as potential antiviral and anticancer agents (Supervisor: D. Komiotis)
  • Fountarlis Dimitrios (2010) Synthesis and possible antioxidant activity of new keto-exomethylene nucleosides with thymine as base (Supervisor: D. Komiotis)
  • Riga Alexandra (2010) Synthesis of flur-sulfur-pyridinyl nucleoside analoges as potential cytarostatic agents (Supervisor: D. Komiotis)
  • Vavilis Theofanis (2010) Synthesis and biological evaluation of triflurmethyluracile ketounsaturated nucleoside (Supervisor: D. Komiotis)
  • Maggas Dimitrios (2010) Synthesis of deoxy cyanopyranonucleoside of uracile as potential antiviral and anticancer agent (Supervisor: D. Komiotis)
  • Panagi Pavlos (2011) Synthesis of new diflurketounsaturated nucleosides as potential cytostatic agents (Supervisor: D. Komiotis)
  • Papakiritsi Mirtila (2011) Synthesis of 5-halogenpyrimidinepyranonucleosides as glycogen phosphorylase inhibitors (Supervisor: D. Komiotis)
  • Gorgogietas Vironas (2012) Synthesis of 3΄-azid-3΄-deoxy glycopznaronucleosite of 5-fluorouracile as potential antiviral and anticancer agent (Supervisor: D. Komiotis)
  • Parmenopoulou Vanesa (2012) Synthesis of new 4΄-cyanonucleosides as potential antiviral and anticancer agents (Supervisor: D. Komiotis)
  • Dimopoulou Athina (2012) Cyano-deoxy-pzranonucleosides as new anticancer and antiviral agents (Supervisor: D. Komiotis)
  • Ksipnitou Andromachi (2012) Synthesis of new 3΄-C-hydroxymethyl-pzranonucleosides as new hypoglycemic agents (Supervisor: D. Komiotis)
  • Kontou Aleksandra (2012) Study of the effect of modified purine-and pyrimidine-nucleosides on the activity of ribonuclease A. (Supervisor: D. Komiotis)
  • Kazali Thomai (2012) 4΄-cyano and 4΄-deoxy pyranonucleosides as new cytostatic agents: synthesis and biological evaluation (Supervisor: D. Komiotis)
  • Garoufas Athanasios (2012) Characterization of hypoglemic agents with spectroscopic methods (Supervisor: D. Komiotis)
  • Kollatos Nikolaos (2012) Synthesis and biological evaluation of 3΄-triflurmethylglycopyranonucleosides (Supervisor: D. Komiotis)
  • Garagkouni Niki-Dimitra (2013) Synthesis and biological evaluation of C-5 substituted glycopyranonucleosides (Supervisor: D. Komiotis)
  • Kaffesaki Eleni (2013) 2΄-cyano pyranonucleosides as new potential antiviral and anticancer agents (Supervisor: D. Komiotis)
  • Papadopoulos Georgios (2013) Characterization of new anticancer nucleosides with spectroscopic methods (Supervisor: D. Komiotis)
  • Zerva Dimitra (2013) Halogonphenylpyrole: Synthesis, antioxidant, anticancer and antiviral evaluation (Supervisor: D. Komiotis)
  • Petrakis Tsampikos (2013) 2΄-cyano and 2΄spyro pyranonucleosides of uracile as new potential anticancer and antiviral agents (Supervisor: D. Komiotis)
  • Thelouras Georgios (2013) Sulfurpyranonucleosides: Synthesis, anticancer and antiviral evaluation (Supervisor: D. Komiotis)
  • Ioannou Eleni (2014) 3΄-Methylnucleosides: Synthesis, and biological evaluation (Supervisor: D. Komiotis)
  • Palios Basilios-Chrysovalantis (2014) Base substituted glycopyranucleosides as potential antiviral and anticancer agents (Supervisor: D. Komiotis)
  • Zisopoulou Stauroula (2014) Halogenmethylphenyl nucleosides as new cytostatic agents (Supervisor: D. Komiotis)
  • Zisis Vasilios (2015) Synthesis and chromatographic analysis of metabolism products of the antioxidant ETHOXYQUIN - Application in monitoring their degradation on organic substrates (Supervisor: D. Komiotis)
  • Molfeta Christina (2015) The creation of a cosmetics production from natural ware (Supervisor: D. Komiotis)
  • Gaka Ioanna (2016)Ν-Ethyl-4-halogenophainylpyrroles: Synthesis and biological evaluation (Supervisor: D. Komiotis)
  • Moraitis Georgios (2016) Design, synthesis and spectroscopic study of new N-β-D-glucopyranosyl-amine as glycogen phosphorylase inhibitors. (Supervisor: D. Komiotis)
  • Karatsoti Evaggelia (2016) Design, synthesis and spectroscopic study of new halogenphenylpyrroloe analogues. Biological evaluation. (Supervisor: D. Komiotis)
  • Karastergiou Athanasios (2016) Synthesis and biological evaluation of C5 halogenphenylpyrrole-substituted pyranonucleosides.(Supervisor: D. Komiotis)
  • Kontopoulou Filitsa (2016) Synthesis, analysis and evaluation of new base modified pyranonucleosides as potential antiviral and cytotoxic agents. (Supervisor: D. Komiotis)
  • Lazaridi Agapi (2017) New modified furanonucleosides as potential antiviral agents. Synthesis and identification by instrumental analysis techniques – spectroscopy. (Supervisor: D. Komiotis)
  • Spandonidis Miltiadis (2017) Design, synthesis and structure determination by spectroscopic analysis of novel halogenphenylpyrrolo derivatives. Biological evaluation. (Supervisor: D. Komiotis)
  • Akribouli Stavroula (2017)Manufacture of pharmaceutical cosmetics from natural products. New soothing and antibacterial cream for use instead of cortisone (Supervisor: D. Komiotis)
  • Sarmas Ilias (2017) Preparation of natural pharmaceutical cosmetics: New osteoarthritis cream with chondroitin and glycosamine to help maintain joint and bone health. (Supervisor: D. Komiotis)
  • Arvanitidou Rafaela (2017) New base modified 3΄-deoxy-furanonucleosides as potentially antiviral and cytotoxic agents. Synthesis, spectroscopic and biological evaluation. (Supervisor: D. Komiotis)
  • Spanos Sotirios (2018) New antiviral agents: Synthesis, characterization by spectroscopic analysis and biological evaluation of novel halogenphenyl pyrrolo derivatives. (Supervisor: D. Komiotis)
  • Andrea Pelagia (2018) New C5-aryl substituted 2-deoxy-furanonucleosides as potential cytotoxic and antiviral agents. (Supervisor: D. Komiotis)
  • Kyrkou Georgia (2018) 3'C-Trifluoromethyl pyranonucleosides as antineoplastic agents: Synthesis, spectroscopic and biological evaluation. (Supervisor: D. Komiotis)
  • Margaritouli Maria-Evagelia (2018) New antiviral agents: Synthesis, spectroscopic and biological evaluation of novel halogenphenylpyrrole derivatives. (Supervisor: D. Komiotis)
  • Tselani Ntaiena (2018) 2'-deoxy-furanonucleosides as novel cytotoxic agents: Design, synthesis and structure determination by spectroscopic analysis. (Supervisor: D. Komiotis)
  • Aleksouli Tania (2019) Modified nucleosides as chemotherapeutic agents. Synthesis, spectroscopic characterization and biological evaluation. (Supervisor: D. Komiotis)
  • Antonaki Styliani-Danai (2019) Design, synthesis, spectroscopic characterization and investigation of the biological action of quinolones and their derivatives. (Supervisor: D. Komiotis)
  • Chatziefremidi Georgia-Anna (2019) Design, synthesis, spectroscopic characterization and biological evaluation of novel halogenophenyl pyrrole derivatives. (Supervisor: D. Komiotis
PhD Thesis  
  • Bioactive unsaturated ketonucleosides. Synthesis and biological evaluation of fluoroketonucleosides of adenine and cytosine. (Stella Manta 2004-2008)
  • Synthesis of novel keto and exomethylene pyranonucleosides with antiviral and cytostatic activity. (Niki Tzioumaki 2006-2010)
  • Synthesis of a novel class of fluoro-sulfur nucleosides with potential antiviral and anticancer activity.(Evangelia Tsoukala 2006-2010)
  • Cyano and ethynyl- pyranonucleosides: Synthesis and evaluation of antiviral and anticancer activity. (Christos Kyritsis 2009-2013)
  • Synthesis and biochemical evaluation of novel modified nucleosides and glucopyranosyl amides. (Vanessa Parmenopoulou 2011-2016)
  • Synthesis of modified on the heterocyclic base pyranonoucleosides as potential antiviral, anticancer and antidiabetic agents. (Athina Dimopoulou 2012-2017)
  • Synthesis of novel trifluoromethyl and difluoromethyl pyranonucleosides with antiviral and cytotoxic activity. (Nikolaos Kollatos in progress)

 

7. Photos:

bioximeia_1 bio_ximeia_5 bioximeia_3

 

8. Useful Links:

 

9. Contact:

Professor D. Komiotis
University of Thessaly
Department of Biochemistry and Biotechnology
Viopolis
41500 Larisa
GREECE
Tel +30-2410-565299
Fax. +30-2410-565290
Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
 
 
 
Special Teaching Staff Christos Mitsos
University of Thessaly
Department of Biochemistry and Biotechnology
Viopolis
41500 Larisa
GREECE
Tel +30-2410-565218
Fax. +30-2410-565290
Email:  This e-mail address is being protected from spambots. You need JavaScript enabled to view it
 
 
 
 
Senior Researcher Niki Tzioumaki
University of Thessaly
Department of Biochemistry and Biotechnology
Viopolis
41500 Larisa
GREECE
Tel +30-2410-565299
Fax. +30-2410-565290
Email:  This e-mail address is being protected from spambots. You need JavaScript enabled to view it
 

Statistics

Members : 3
Content : 298
Web Links : 71
Content View Hits : 3219011
We have 294 guests online

Images

ad1.jpg
  • Πανεπιστήμιο Θεσσαλίας
  • Πανεπιστήμιο Θεσσαλίας
  • Πανεπιστήμιο Θεσσαλίας
  • Πανεπιστήμιο Θεσσαλίας
  • Πανεπιστήμιο Θεσσαλίας
  • Πανεπιστήμιο Θεσσαλίας
escort ankara porno izle sikiş ukash