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MOLECULAR VIROLOGY - MOLECULAR BACTERIOLOGY

         Selections
1. Brief Description 6. Thesis
2. Research Interests 7. Photos
3. Personnel 8. Useful links
4. Funded Research Projects 9. Contact
5. Publications    

 

1. Brief Description:

The laboratory of Microbiology - Virology of the Department of Biochemistry & Biotechnology was created in February 2004. The laboratory is implicated in teaching undergraduate and postgraduate students and conducting basic and applied research projects in the field of molecular Virology with undergraduate and postgraduate students and Ph.D candidates. Director of the lab is the professor of Applied Microbiology, Panayotis Markoulatos.

2. Research Interests:

Enteroviruses, Noroviruses, HPV viruses

Viruses use the host-cell systems throughout their life cycle to infect, replicate and re-infect. Consequently, the ‘genomics revolution’ offers high-throughput tools to study the complex virus–host interaction with changing expression levels of many genes and gene pathways as a direct function of viral and host genome properties. Our on-going research projects   focus on enteroviruses, noroviruses and on oncogenic HPV-16 viruses genomics and on functional genomics in host-pathogen interactions, trying to give answers to questions such as: are changes in gene expression during viral challenge a cellular-defence mechanism, a virally induced response necessary for the virus or a functional and probably therapeutically and diagnostically relevant by product of viral infection? These studies aimed to elucidate the processes involved in viral pathogenesis and will ultimately allow the development of new diagnostics and therapeutics improving the management of infectious diseases.

Molecular microbiology with emphasis on pseudomonad biology (High-affinity iron uptake systems, oxidative stress, cyanogenesis, gene regulation, antibiotic resistance) Biotechnological Application of pseudomonads in Agriculture and Environment. Characterization of microbiota in insects (Cydia pomonella) and aquacultures fishes (DicentrarchuslabraxL.). Antimicrobial properties of Greek honey. Microbial diversity of biodeteriorated art and historical objects (e.g. manuscripts, wall paintings).


3. Personnel:

Head of the Lab:

Professor Panayotis Markoulatos
Assistant Professor Dimitrios Mossialos

 

 4. Funded Research Projects:

Funding list 1995-2014

  • Molecular Approaches for the detection and identification of Enteroviruses. Duration: 1/2/1995-31/1/1998
  • Experimental Application of urban and animal sewages with appropriate, new technology dropping devices. Environmental Virology. Duration: 1/3/1995-28/2/1998
  • National Center for Poliomyelitis and Enteroviruses. Duration: 1/1/1997-31/12/9
  • National Influenza Center. Duration: 1/1/1997-31/12/97
  • Detection and characterization of Capripox viruses by molecular approaches. Duration: 1/1/1997 – 31/12/99
  • Immunology ofCapripoxvirus. Duration: 1/4/98-31/3/2000
  • Recherche des recombinants chez des virus ARN de polarite positive (enterovirus et virus de l’hepatite C). Duration: 1/9/98-30/8/2000
  • Etude de la circulation et de la variabilité génétique des souches du VPO. Duration: 1/10/99- 1/10/2002
  • Maladies Emergentes. Duration: 1/5/00-1/5/01
  • Investigation of the in trans complemetnation of poliovirus non-structural protein functions. Duration: 7/12/00-7/12/02
  • Phylogenetic sequence analysis and improved diagnostic assay systems for viruses of the family Reoviridae. Duration: 1/1/01-31/12/03
  • National Centre for Poliomyelitis and Enteroviruses. Duration: 1/9/01-1/10/02
  • Circulation et variabilité génétique des enterovirus et des souches du vaccin oral. Duration 1/1/03 – 31/12/04
  • Entérovirus – Diagnostic moléculaire des enterovirus. Duration 1/1/04 – 31/12/05 
  • National Centre for Poliomyelitis and Enteroviruses. Duration 1/1/04- 31/10/04
  • Potency testing of trivalent oral poliovirus (OPV) vaccine (Sabin). Duration 1/4/04-31/3/06
  • Detection of Enterovirus in sewage. Duration 1/4/04- 31/3/06
  • Molecular detection of Enteroviruses in clinical samples and the environment. “Implications for the public health”. Duration 1/1/05- 31/12/06
  • Genetic recombination of circulating  enteroviruses. Duration 1/2/06 – 31/1/08
  • Postgraduate Program “Biotechnology”, code 3439, of the University of Thessaly, School of Health Sciences, Department of Biochemistry & Biotechnology. Duration 1/3/08 -
  • Postgraduate Program “Applications of Molecular Biology-Genetics. Diagnostic Biomarkers”, code 3817, of the University of Thessaly, School of Health Sciences, Department of Biochemistry & Biotechnology. Duration 1/3/09 –

 5. Publications:

Recent Puplications 1.1.2010 - 1.10.2015

  1. Pliaka V, Dedepsidis E, Kyriakopoulou Z, Mpirli K, Tsakogiannis D, Pratti A, Levidiotou- Stefanou S, Markoulatos P (2010). A new RT-PCR assay for the identificationthe predominant recombination types in 2C and 3D genomic regions of vaccine-derived poliovirus strains. Mol Cell Probes. Jun; 24(3):115-23.
  2. Kyriakopoulou Z, Dedepsidis E, Pliaka V, Mastorakos P, Stamati A, Pratti A, Levidiotou-Stefanou S, Markoulatos P (2010). Molecular identification and full genome analysis of an echovirus 7 strain isolated from the environment in Greece. Virus Genes ;40(2):183-92.
  3. Pliaka V, Dedepsidis E, Kyriakopoulou Z, Papadi G, Tsakogiannis D, Pratti A, Levidiotou-Stefanou S, Markoulatos P (2010). Growth kinetic analysis of bi-recombinant poliovirus vaccine strains. Virus Genes ;40(2):200-11.
  4. Kyriakopoulou Z, Dedepsidis E, Pliaka V, Tsakogiannis D, Pratti A, Levidiotou-Stefanou S, Markoulatos P (2010). Full-genome sequence analysis of aechovirus 3 strain isolated from sewage in Greece. J Clin Microbiol. ;48(5):1513-9.
  5. Katsarou K, Lavdas AA, Tsitoura P, Serti E, Markoulatos P, Mavromara P, Georgopoulou U (2010). Endocytosis of hepatitis C virus non-enveloped capsid-like particles induces MAPK-ERK1/2 signaling events .Cell Mol Life Sci.;67(14):2491-506.
  6. Pliaka V, Ruether I, Kyriakopoulou Z, Kioussi P, Plakokefalos E, Megalou M, Pratti A, Levidiotou-Stefanou S, Markoulatos P (2010). A seroprevalence study of Poliovirusagainst a collection of recombinant and non-recombinant Poliovirus vaccinal strains in population of Southern Greece. Clin Microbiol Infect. 16:1669-1675.
  7. Dedepsidis E., Kyriakopoulou Z., Pliaka V., Markoulatos P.(2010). Correlation between recombination junctions and RNA secondary structurein   Poliovirus   Sabin strains. Virus Genes ,41 (2): 181-91.
  8. Pliaka V., Achilleos C.,Kyriakopoulou Z., Tsakogiannis D., Ruether IGA., Gartzonica C., Levidiotou-Stefanou S., Markoulatos P. (2010).Determination of antigenic properties of vaccine derived poliovirus strains. Vaccine 10, 29 (1): 26-33.
  9. Pliaka V., Kyriakopoulou Z., Tsakogiannis D., Ruether I.G.A, Gartzonika C., Levidiotou-Stefanou S., Krikelis A., Markoulatos P. (2010). Correlation of mutations and recombination with growth kinetics of Poliovirus vaccine strains . Eur J of Clin Microbiol and Infect Dis , 29 (12):1513-23.
  10. Boumlic A., Vassilaki N., Dalagiorgou G.,Kochlios E.,Kakkanas A., Georgopoulou U., Markoulatos P., Orfanoudakis G., Mavromara P.(2010). Internal translation initiation stimulates expression of the ARF/core+1 open reading frame of HCV genotype 1b.Virus Res 155 (1):213-220
  11. Kyriakopoulou Z., Dedepsidis E., Pliaka V., Tsakogiannis D., Ruether I. G. A., Krikelis,   Markoulatos P. (2011). Complete nucleotide sequence analysis of VP1 genomic region of Echoviruses 6 isolated from sewages in Greece revealed 98% similarity with Echoviruses 6 that were characterized from an aseptic meningitis outbreak one year later. Clin Microbiol Infect ,17 (8): 1170-3
  12. .Pliaka V, Filliponi ME, Kyriakopoulou Z, Ruether IG, Tsakogiannis D, Gartzonika C, Levidiotou-Stefanou S, Markoulatos P.(2011). Retrospective molecular and phenotypic analysis of poliovirus vaccine strains isolated in Greece. Clin Microbiol Infect. 17 (10):1554-62
  13. Kyriakopoulou Z., Pliaka V., Tsakogiannis D., Ruether IG.,Komiotis D., Gartzonika C.,Levidiotou-Stefanou S., Markoulatos P. (2012). Genome analysis of two type 6 echovirus (E6) strains recovered from sewage specimens in Greece in 2006. Virus Genes 44 (2):207-16
  14. Ruether IG., Tsakogiannis D., Pliaka V., Kyriakopoulou Z., Krikelis A.,Gartzonika C.,Levidiotou-Stefanou S.,Markoulatos P.(2012). Molecular characterization of a new intergenotype Norovirus GII recombinant. Virus Genes 44 (2):237-43
  15. Tsakogiannis D., Ruether IG., Kyriakopoulou Z., Pliaka V.,Theoharopoulou A., Skordas V.,Panotopoulou E., Nepka C., Markoulatos P. (2012). Sequence variation analysis of the E2 gene of human papilloma virus type 16 in cervical lesions from women in Greece. Arch. Virol.157 (5):825-32
  16. Pliaka V., Kyriakopoulou Z., Markoulatos P., (2012). Risks associated with the use of live attenuated vaccine poliovirus strains and the strategies for control and eradication of paralytic poliomyelitis. Expert Rev. Vaccines 11 (5):609-628
  17. Tsakogiannis D.,Ruether IG., Kyriakopoulou Z., Pliaka V., Skordas V., Gartzonika C., Levidiotou-Stefanou S., Markoulatos P., (2012). Molecular and phylogenetic analysis of the HPV 16 E4 gene in cervical lesions from women in Greece. Arch Virol. 2012 Sep;157(9):1729-39.
  18. Kyriakopoulou Z., Tsolis K.,Pliaka V., Tsakogiannis D.,Ruether IGA., Gartzonika C.,Levidiotou-Stefanou S., Markoulatos P., (2013). Combined 5’ UTR RFLP analysis and VP1 sequencing for epidemic investigation of enteroviruses. Arch. Virol. 158 (1): 103-11
  19. Tsakogiannis D., Kyriakopoulou Z., Amoutzias G., Ruether IGA.,Dimitriou TG., Panotopoulou E., Markoulatos P., (2013).Identification of novel E6-E7 sequence variants of human papillomavirus 16.   Arch. Virol. 158 (4) : 821-8
  20. Tsakogiannis D, Papadopoulou A, Kontostathi G, Ruether IG., Kyriakopoulou Z., Dimitriou TG, Orfanoudakis G, Markoulatos P., (2013). Molecular and evolutionary analysis of HPV16 E6 and E7 genes in Greek women. J Med Microbiol. 62:1688-96
  21. Tsakogiannis D., Darmis F., Gortsilas P., Ruether IGA., Kyriakopoulou Z., Dimitriou TG.,   Amoutzias G., Markoulatos P., (2014).Nucleotide polymorphisms of the human papillomavirus 16 E1 gene. Arch Virol. 159(1):51-63
  22. Ruether IG, Tsakogiannis D, Kyriakopoulou Z, Dimitriou TG, Papamichail C, Gartzonika C, Leveidiotou-Stefanou S, Markoulatos P., (2014). Circulation of intergenotype recombinant noroviruses GII.9/GII.6 from 2006 to 2011 in central Greece.Virus Genes.48(1):23-31.
  23. Tsakogiannis D, Kyriakopoulou Z, Darmis F, Ruether IG, Dimitriou TG, Orfanoudakis G, Panotopoulou E, Markoulatos P., (2014). Prevalence of HPV16 E1-1374^63nt variants in Greek women . J Med Virol. 86(5):778-84.
  24. Dimitriou TG, Pliaka V, Kyriakopoulou Z, Ruether IG, Tsakogiannis D, Fountoucidou P, Gartzonika C, Levidiotou-Stefanou S, Markoulatos P., (2014).PCR assays for the identification of rare recombination types from VP1 to 3D genomic region of vaccine derived poliovirus strains. Mol Cell Probes. 28(4):107-12.
  25. Ruether IG, Dimitriou TG, Tsakogiannis D, Kyriakopoulou Z, Amoutzias GD, Gartzonika C, Levidiotou-Stefanou S, Markoulatos P.,(2014). Characterization of novel intergenogroup and intergenotype recombinant noroviruses from central Greece. Mol Cell Probes. 28(4):204-10.
  26. Tsakogiannis D, Kyriakopoulou Z, Ruether IG, Amoutzias GD, Dimitriou TG, Diamantidou V, Kotsovassilis C, Markoulatos P., (2014).Determination of human papillomavirus 16 physical status through E1/E6 and E2/E6 ratio analysis. J Med Microbiol. 63:1716-23.
  27. Tsakogiannis D, Diamantidou V, Toska E, Kyriakopoulou Z, Dimitriou TG, Ruether IG, Gortsilas P, Markoulatos P., (2015). Multiplex PCR assay for the rapid identification of human papillomavirus genotypes 16, 18, 45, 35, 66, 33, 51, 58, and 31 in clinical samples. Arch Virol. 160(1):207-14.
  28. Tsakogiannis D, Papacharalampous M, Toska E, Kyriakopoulou Z, Dimitriou TG, Ruether IG, Komiotis D, Markoulatos P., (2015). Duplex Real-time PCR assay and SYBR green I melting curve analysis for molecular identification of HPV genotypes 16, 18, 31, 35, 51 and 66. Mol Cell Probes Feb;29(1):13-8
  29. Kyriakopoulou Z, Pliaka V, Amoutzias GD, Markoulatos P, (2015). Recombination among human non-polio enteroviruses: implications for epidemiology and evolution. Virus Genes Apr;50(2):177-88.
  30. Tsakogiannis D, Gortsilas P, Kyriakopoulou Z, Ruether IG, Dimitriou TG, Orfanoudakis G, Markoulatos P, (2015). Sites of disruption within E1 and E2 genes of HPV16 and association with cervical dysplasia. J Med Virol Nov;87(11):1973-80.
  31. Kyriakopoulou Z, Bletsa M, Tsakogiannis D, Dimitriou TG, Amoutzias GD, Gartzonika C, Levidiotou-Stefanou S, Markoulatos P, (2015). Molecular epidemiology and evolutionary dynamics of Echovirus 3 serotype. InfectGenetEvolJun;32:305-12.

 Publications "Molecular Bacteriology"

  1. Nikolouli K. and D. Mossialos (2015) Functional characterization of TtgABC efflux pump of the RND family in the entomopathogenic bacterium Pseudomonas entomophila. Ann. Microbiol. Epub 2015 June 26
  2. Mathioudakis M.M., R.S. Veiga, T. Canto, V. Medina, D. Mossialos, A.M. Makris and I. Livieratos (2013) Pepino mosaic virus triple gene block protein 1 (TGBp1) interacts with and increases tomato catalase 1 activity to enhance virus accumulation. Mol. Plant Pathol. 14(6): 589-601
  3. Pournaras S., R. Kock, D. Mossialos, A. Mellmann, V. Sakellaris, C. Stathopoulos, A.W. Friedrich and A. Tsakris (2013) Detection of a phylogenetically distinct IMP-type metallo-β-lactamase, IMP-35, in CC235 Pseudomonas aeruginosa from Dutch-German border region (Euregio). J. Antimicrob. Chemother. 68(6): 1271-1276
  4. Anthimidou E. and D. Mossialos* (2013) Antibacterial activity of Greek and Cypriot honeys against Staphylococcus aureus and Pseudomonas aeruginosa in comparison to manuka honey. J. Med. Food 16(1): 42-47
  5. Stagos D., N. Portesis, C. Spanou, D. Mossialos, N. Aligiannis, E. Chaita, C. Panagoulis, E. Reri, L. Skaltsounis, A.M. Tsatsakis and D. Kouretas (2012) Correlation of total polyphenolic content with antioxidant and antibacterial activity of 24 extracts from Greek domestic Lamiaceae species. Food Chem Toxicol. 50(11): 4115-4124
  6. Nikolouli K. and D. Mossialos* (2012) Bioactive compounds synthesized by non-ribosomal peptide synthetases ans type-I polyketide synthases discovered through genome-mining and metagenomics. Biotechnol. Lett. 34(8): 1393-1403
  7. Amoutzias, G.D., Y. He, J. Gordon, D. Mossialos, S.G. Oliver and Y. Van De Peer (2010) Posttranslational regulation impacts the fate of duplicated genes. Proc. Natl. Acad. Sci USA 107(7): 2967-2971
  8. Papagiannoulis A., K.D. Mathiopoulos and D. Mossialos* (2010) Molecular detection of the entomopathogenic bacterium Pseudomonas entomophila using Polymerase Chain Reaction (PCR). Lett. Appl. Microbiol 50(3): 241-245.
  9. Ryall, B., H. Mitchell, D. Mossialos* and H.D. Williams (2009) Cyanogenesis by the entomopathogenic bacterium Pseudomonas entomophila. Lett. Appl. Microbiol. 49(1): 131-135
  10. Humair, B., N. Gonzalez, D. Mossialos, C. Reimmann and D. Haas (2009) Temperature-responsive sensing regulates biocontrol factor expression in Pseudomonas fluorescens CHA0. ISME J. 3(8): 955-965
  11. Mossialos, D.* and G.D. Amoutzias (2009) Role of siderophores in cystic fibrosis pathogenesis: foes or friends? Int. J. Med. Microbiol. 299 (2): 87-98.
  12. Amoutzias, G., Y., Van de Peer, and D. Mossialos*. (2008) Evolution and taxonomic distribution of nonribosomal peptide and polyketide synthases. Future Microbiol. 3: 361-370.
  13. Mossialos, D.* and Amoutzias G. (2007) Siderophores in fluorescent pseudomonads: new tricks from an old dog. Future Microbiol. 2:387-395.
  14. Ramstedt, M., R., Houriet, D., Mossialos, D., Haas, and HJ Mathieu. (2007) Wet chemical silver treatment of endotracheal tubes to produce antibacterial surfaces. J. Biomed. Mater. Res. B Appl. Biomater. 83(1): 169-180
  15. Ramstedt, M., N., Cheng, O., Azzaroni, D., Mossialos, H.J., Mathieu and W.T. Huck. (2007) Synthesis and characterization of Poly (3-sulfopropylethacrylate) brushes for potential antibacterial applications. Langmuir: 23(6): 3314-3321.

6. Thesis: 

Supervision of 20 Master Degree students’ projects in Biotechnology - Molecular Virology, entitled:

  1. “Detection of enteroviruses in drinking water. EEC directives for drinking water must include the enteroviruses detection?”, 2009. Department of Biochemistry & Biotechnology,UniversityThessaly.
  2. “Molecular characterization of ECHO viruses by sequencing of genomic regions VP1, VP2, VP3 and VP4”, 2009. DepartmentBiochemistry & Biotechnology, University of Thessaly.
  3. “Integration of HPV-16 genome to the host DNA. May the integration site be used as a molecular biomarker towards neoplasia?”, 2010. DepartmentBiochemistry & Biotechnology, University   of Thessaly.
  4. “PCR arrays for the detection and the molecular characterization of Noroviruses from sewages”, 2010. Department of Biochemistry & Biotechnology, University of Thessaly.
  5. “Detection of recombination sites and mutations through the entire genome of a poliovirus strain”, 2010. Department of Biochemistry & Biotechnology, University of Thessaly.
  6. “Detection of Noroviruses in drinking water. EEC directives for drinking water must include the noroviruses detection?”, 2010. Department of Biochemistry & Biotechnology, UniversityThessaly.
  7. “High risk HPV viruses. mRNAs of E6 and E7 oncogenes may be used as molecular biomarkerthe evolution from CINI towards CIN III and from CIN III to neoplasia?” , 2010. Department of   Biochemistry & Biotechnology, University of Thessaly.
  8. “PCR arrays for the detection and molecular characterization of Echo viruses”, 2011. Department of Biochemistry & Biotechnology, University of Thessaly.
  9. “Mapping of disruption sites of E1 and E2 genes of HPV-16 in high and low grade dysplasia”, 2011. Department of Biochemistry & Biotechnology, University of Thessaly.
  10. “Development of a real time PCR for the quantification of E2, E6 and E7 genes of HPV16”, 2012. Department of Biochemistry & Biotechnology, Universityof Thessaly.
  11. “Phylogenetic analysis of E4 gene in HPV-16 clinical strains. Mutations in E4 genomic region are correlated with the degree of dysplasia? The non-European strains are correlated with neoplasia ?”, 2012.Department of Biochemistry & Biotechnology, University of Thessaly.
  12. “HPV-16,-18,-31,-33 .The mRNAs of E6 and E7 oncogenes may be used as a molecular biomarquer for the progression from CIN I to CIN III?”, 2012. Department of Biochemistry & Biotechnology, University of Thessaly.
  13. “PCR arrays for the detection of 8 high risq HPVs (HPVs -16,-18,-33,-35,-45,-51,-58,-66), 2012. Department of Biochemistry & Biotechnology, University of Thessaly.
  14. “Development of a Multiplex RT-PCR assay for the identification of rare recombination types at genomic regions of vaccine-derived polioviruses”, 2013. Department of Biochemistry & Biotechnology, University of Thessaly.
  15. “Development of a multiplex PCR for the detection and molecular characterization of high-risk HPV types -16, -18, -45, -58, -51, -66, -35, -33, -31”, 2013. Department of Biochemistry & Biotechnology, University of Thessaly.
  16. “Molecular detection of GI Noroviruses from environmental samples through sequencing”, 2013. Department of Biochemistry & Biotechnology, University of Thessaly.
  17. “Molecular and phylogenetic analysis of GII Noroviruses from clinical and environmental samples”, 2013. Department of Biochemistry & Biotechnology, University of Thessaly.
  18. “Mapping and molecular analysis of integration sites of HPV16 in the human genome”, 2014. Department of Biochemistry & Biotechnology, University of Thessaly.
  19. “Development of a real-time multiplex PCR for the detection and molecular characterization of high-risk HPV types 16, 18, 31, 33, 35, 51, 66”, 2014. Department of Biochemistry & Biotechnology, University of Thessaly
  20. “Determination of HPV-16 physical status through E1/E6 and E2/E6 copy number ratio analysis”, 2015. Department of Biochemistry & Biotechnology, University of Thessaly

           Supervision of 13 Ph.D. students in Molecular Virology

Twelve PhD. Thesis have been already accomplished and one is in progress:

  1. Detection and typing of polioviruses, Coxsackie B viruses and ECHO viruses using molecular techniques". Department of Biology - Genetics, School of Medicine, University of Thessaly, October 2001.
  2. "Molecular Classification of Coxsckie A viruses on the basis of 5’-UTR using RFLP analysis and sequencing: structural and evolutionary aspects". Department of Biological Sciences, University of Essex, Great Britain, November 2001.
  3. "Detection and identification of influenza viruses using molecular techniques". Department of Biology - Genetics, School of Medicine, University of Thessaly, June 2002.
  4. "Detection and molecular identification of enteroviruses in HIV patients and in the environment. Implications for the public health». Medical School, University of Ioannina, November 2005.
  5. «Molecular detection, classification and comparative genomics of Coxsackie A & B enteroviruses on VP1 genomic region». Department of Cell Biology and Biophysics, University of Athens, July 2007.
  6. «Molecular identificationgenome evolution of Echoviruses». Department of Biochemistry and Biotechnology, University of Thessaly, November 2007.
  7. "Poliovirus OPV strains- Correlation between recombination and RNA secondary structures". Department of Biochemistry and Biotechnology, University of Thessaly, July 2008.
  8. "Recombinant poliovirus strains – sites of genetic recombination". Department of Biochemistry and Biotechnology, University of Thessaly,2009.
  9. “Molecular detection of Noroviruses-Polioviruses in the environment. Identification of genetic recombinations and correlation with the replication efficiency of viral strains”. Department of Biochemistry and Biotechnology, University of Thessaly, March 2010.
  10. “Molecular detection of enteroviruses in the environment and characterization of recombinations sites in circulating enteroviruses in the environment”. Department of Biochemistry and Biotechnology, University of Thessaly, March 2010.
  11. “Molecular and phylogenetic analysis of Noroviruses”. Department of Biochemistry and Biotechnology, University of Thessaly, March 2014.
  12. “Determination of the physical status of HPV 16 genome,correlation with the CINs profile of patients and determination of the integration site of HPV16 in human genome”.Department of Biochemistry and Biotechnology, University of Thessaly, March 2014.

7. Photos: 

Molecular Virology

 

 

8. Useful Links: 

 

 

9. Contact:

Markoulatos    Panayotis
University of Thessaly
Department of Biochemistry and Biotechnology
Viopolis
41500 Larissa
GREECE
Tel. +30 2410  565274
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
 
Mossialos Dimitrios
 

 

 
 

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