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STRUCTURAL & FUNCTIONAL BIOCHEMISTRY

 
Selections
1. Brief Description 6. Thesis
2. Research Interests 7. Lab equipment
3. Personnel 8. Useful links
4. Funded Research Projects 9. Photos
5. Publications  10.   Contact

1. Brief Description:

The Structural and Functional Biochemistry Laboratory (SFBL) serves the educational and research needs in the disciplines of Biochemistry (intermediate metabolism, synthesis and nucleic acid metabolism, structure and function of proteins), Biophysics, Structural Biochemistry, Proteomics, Structural Genomics, Regulation of metabolism, Metabolic Control of Enzymes and the implementation of all the above in Analytical Biochemistry, Enzymology Clinical Biochemistry, Food Biochemistry, Chemical Biology and Structure-Driven Drug Design.

2. Research interests:

SFLB activities are directed to research on structural and functional aspects of macromolecules of pharmaceutical and biotechnological interest and structure-based drug design. The main directions of the SFBL activities is the rational design, synthesis, and evaluation of molecules against major diseases with a current emphasis on type 2 diabetes, angiogenesis, cancer, inflammation, and thrombosis. In particular research in SFBL aims to elucidate the relationship between structure/function of enzymes involved in glycogen metabolism, ribonucleases of the pancreatic ribonuclease A superfamily, deadenylases which are the enzymes that degrade poly(A) tails regulating mRNA turnover rates mitochondrial steroid hormone receptors, and gene expression and homeostasis factors. Specific project within the laboratory are as follows:

Biochemical studies of enzymes in glycogen metabolism

Design of deadenylase inhibitors with therapeutic potential

Structure-based drug design of ribonuclease inhibitors

Characterization and function of the mitochondrial steroid hormone receptors.

Elucidation of the control, diversity and biological functions of deadenylases

Structural basis of carbohydrate recognition by lectins.

Molecular Modeling

 
3. Personnel:


Post doctoral:

  • Dr. Arsenopoulou Zoi Dr
  • Dr. Drakou Christina
  • Dr. Stravodimos A. Georgios

    Phd Students:

       Antonopoulos Dionysios, BSc, MSc
Kalousi Foteini, BSc, MSc
Karra Aikaterini, BSc, MSc
Koulas Symeon, BSc, MSc
Kyriakis Efthymios, BSc, MSc
Kiritsis Athanasios, BSc, MSc,
Beta Rafaelia, BSc, MSc
Papaioannou Olga, BSc, MSc
Solovou Theodora, BSc, MSc
Tsagkarakou Anastasia, BSc, MSc
Tsialtas Ioannis, BSc, MSc

Master Students
Alexopoulos Sefis, BSc 
Asimakopoulos Dimitrios, BSc
Georgantopoulos Achilleas, BSc
 Gkantounas Ioannis, BSc
Theodosi Antrea, BSc
Moustaka Renia, BSc
Rizouli Marianna, BSc
Tsiara Sofia, BSc

       Undergraduate Students

·        Dalkidis Dimitrios
Meras Vasillis
Mechmetoglou Feride
Papadimitriou Natalie
Stergiou Dimitra
 Christodoulou Stefanos

 

4. Funded Research projects:
  • 2018-2021:The National Research Infrastructures on integrated biology, drug screening efforts and drug target functional characterization – INSPIRED” (MIS 5002550) which is implemented under the Action “Reinforcement of the Research and Innovation Infrastructure”, funded by the Operational Programme "Competitiveness, Entrepreneurship and Innovation" (NSRF 2014-2020) and co-financed by Greece and the European Union (European Regional Development Fund). INSPIRED-Thessaly, D.D. Leonidas (Coordinator), V.T. Skamnaki.

  • 2018-2021 Synthetic Biology: From omics technologies to genomic engineering (OMIC-ENGINE)» (MIS 5002636) Synthetic Biology: From omics technologies to genomic engineering (OMIC-ENGINE)” (MIS 5002636) which is implemented under the Action “Reinforcement of the Research and Innovation Infrastructure”, funded by the Operational Programme "Competitiveness, Entrepreneurship and Innovation" (NSRF 2014-2020) and co-financed by Greece and the European Union (European Regional Development Fund). D.D. Leonidas, A.M. Psarra, N. Balatsos, G. Papadopoulos, V.T. Skamnaki

  •  2019-2020: Structure based design of glycogenolysis regulators for the development of new therapeutic agents. «Researchers support with emphasis on young researchers – second cycle» NSRF 2014-2020. D.D. Leonidas (Coordinator), A.M. Psarra.

  • 2019-2020: Investigation of the role of poly (A) -specific ribonuclease in circadian gene expression. ««Researchers support with emphasis on young researchers – second cycle» NSRF 2014-2020. N. Balatsos (Coordinator).

  •    2019-2020: MicroRNAs that modulate deadenylase expression in lung cancer.«Hellenic Thoracic Society», N. Balatsos (Coordinator).
 
5. Publications (2005 - ):
1.     Glucopyranosylidene-spiro-imidazolinones, a New Ring System: Synthesis and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetics and X-ray Crystallography. Szabó KE, Kyriakis E, Psarra AG, Karra AG, Sipos Á, Docsa T, Stravodimos GA, Katsidou E, Skamnaki VT, Liggri PGV, Zographos SE, Mándi A, Király SB, Kurtán T, Leonidas DD, Somsák L. J Med Chem. 2019 Jul 11;62(13):6116-6136.
2.     The mast cell - neurofibromatosis connection. Antonopoulos D, Tsilioni I, Balatsos NAA, Gourgoulianis KI, Theoharides TC. J Biol Regul Homeost Agents. 2019 May-Jun,;33(3):657-659.
3.     High Consistency of Structure-Based Design and X-Ray Crystallography: Design, Synthesis, Kinetic Evaluation and Crystallographic Binding Mode Determination of Biphenyl-N-acyl-β-d-Glucopyranosylamines as Glycogen Phosphorylase Inhibitors. Fischer T, Koulas SM, Tsagkarakou AS, Kyriakis E, Stravodimos GA, Skamnaki VT, Liggri PGV, Zographos SE, Riedl R, Leonidas DD. Molecules. 2019 Apr 3;24(7).
4.     Effect of honey on glucose and insulin concentrations in obese girls. Farakla I, Koui E, Arditi J, Papageorgiou I, Bartzeliotou A, Papadopoulos GE, Mantzou A, Papathanasiou C, Dracopoulou M, Papastamataki M, Moutsatsou P, Papassotiriou I, Chrousos GP, Charmandari E. Eur J Clin Invest. 2019 Feb;49(2).
5.     New Chloramphenicol Derivatives from the Viewpoint of Anticancer and Antimicrobial Activity. Giannopoulou PC, Missiri DA, Kournoutou GG, Sazakli E, Papadopoulos GE, Papaioannou D, Dinos GP, Athanassopoulos CM, Kalpaxis DL. Antibiotics (Basel). 2019 Jan 29;8(1).
6.     Potential Dissociative Glucocorticoid Receptor Activity for Protopanaxadiol and Protopanaxatriol. Karra AG, Konstantinou M, Tzortziou M, Tsialtas I, Kalousi FD, Garagounis C, Hayes JM, Psarra AG. Int J Mol Sci. 2018 Dec 27;20(1).
7.     Urine concentrations changes of cysteinyl leukotrienes in non-obese children with obstructive sleep apnea undergoing adenotonsillectomy. Mousailidis GΚ, Lachanas VA, Vasdeki A, Alexopoulos EI, Kaditis AG, Petinaki E, Balatsos NAA, Bizakis JG, Skoulakis CE. Int J Pediatr Otorhinolaryngol. 2018 Dec;115:149-152.
8.     Toward fully exploiting the therapeutic potential of marketed pharmaceuticals: the use of octreotide and chloroquine in oncology. Papanagnou P, Papadopoulos GE, Stivarou T, Pappas A. Onco Targets Ther. 2018 Dec 31;12:319-339.
9.     Potential interference of aluminum chlorohydrate with estrogen receptor signaling in breast cancer cells. Gorgogietas VA, Tsialtas I, Sotiriou N, Laschou VC, Karra AG, Leonidas DD, Chrousos GP, Protopapa E, Psarra AG. J Mol Biochem. 2018;7(1):1-13.
10.  Amino acid signatures in the HLA class II peptide-binding region associated with protection/susceptibility to the severe West Nile Virus disease. Sarri CA, Papadopoulos GE, Papa A, Tsakris A, Pervanidou D, Baka A, Politis C, Billinis C, Hadjichristodoulou C, Mamuris Z; MALWEST project. PLoS One. 2018 Oct 31;13(10).
11.  Positioning Europe for the EPITRANSCRIPTOMICS challenge. Jantsch MF, Quattrone A, O'Connell M, Helm M, Frye M, Macias-Gonzales M, Ohman M, Ameres S, Willems L, Fuks F, Oulas A, Vanacova S, Nielsen H, Bousquet-Antonelli C, Motorin Y, Roignant JY, Balatsos N, Dinnyes A, Baranov P, Kelly V, Lamm A, Rechavi G, Pelizzola M, Liepins J, Holodnuka Kholodnyuk I, Zammit V, Ayers D, Drablos F, Dahl JA, Bujnicki J, Jeronimo C, Almeida R, Neagu M, Costache M, Bankovic J, Banovic B, Kyselovic J, Valor LM, Selbert S, Pir P, Demircan T, Cowling V, Schäfer M, Rossmanith W, Lafontaine D, David A, Carre C, Lyko F, Schaffrath R, Schwartz S, Verdel A, Klungland A, Purta E, Timotijevic G, Cardona F, Davalos A, Ballana E, O Carroll D, Ule J, Fray R. RNA Biol. 2018;15(6):829-831.
12.  Tales around the clock: Poly(A) tails in circadian gene expression. Beta RAA, Balatsos NAA. Wiley Interdiscip Rev RNA. 2018 Jun 17:e1484.
13.  Probing the β-pocket of the active site of human liver glycogen phosphorylase with 3-(C-β-d-glucopyranosyl)-5-(4-substituted-phenyl)-1, 2, 4-triazole inhibitors. Kyriakis E, Solovou TGA, Kun S, Czifrák K, Szőcs B, Juhász L, Bokor É, Stravodimos GA, Kantsadi AL, Chatzileontiadou DSM, Skamnaki VT, Somsák L, Leonidas DD. Bioorg Chem. 2018 Apr;77:485-493.
14.  A multidisciplinary study of 3-(β-d-glucopyranosyl)-5-substituted-1,2,4-triazole derivatives as glycogen phosphorylase inhibitors: Computation, synthesis, crystallography and kinetics reveal new potent inhibitors. Kun S, Begum J, Kyriakis E, Stamati ECV, Barkas TA, Szennyes E, Bokor É, Szabó KE, Stravodimos GA, Sipos Á, Docsa T, Gergely P, Moffatt C, Patraskaki MS, Kokolaki MC, Gkerdi A, Skamnaki VT, Leonidas DD, Somsák L, Hayes JM. Eur J Med Chem. 2018 Mar 10;147:266-278.
15.  Affinity Crystallography Reveals the Bioactive Compounds of Industrial Juicing Byproducts of Punica granatum for Glycogen Phosphorylase. Stravodimos GA, Kantsadi AL, Apostolou A, Kyriakis E, Kafaski-Kanelli VN, Solovou T, Gatzona P, Liggri PGV, Theofanous S, Gorgogietas VA, Kissa A, Psachoula C, Lemonakis A, Chatzileontiadou DSM, Psarra AG, Skamnaki VT, Haroutounian SA, Leonidas DD. Curr Drug Discov Technol. 2018;15(1):41-53.
16.  Evidence for Novel Action at the Cell-Binding Site of Human Angiogenin Revealed by Heteronuclear NMR Spectroscopy, in silico and in vivo Studies. Chatzileontiadou DSM, Tsika AC, Diamantopoulou Z, Delbé J, Badet J, Courty J, Skamnaki VT, Parmenopoulou V, Komiotis D, Hayes JM, Spyroulias GA, Leonidas DD. ChemMedChem. 2018 Feb 6;13(3):259-269. doi: 10.1002/cmdc.201700688. Epub 2018 Jan 15.
17.  The In Vitro Impact of the Herbicide Roundup on Human Sperm Motility and Sperm Mitochondria. Anifandis G, Amiridis G, Dafopoulos K, Daponte A, Dovolou E, Gavriil E, Gorgogietas V, Kachpani E, Mamuris Z, Messini CI, Vassiou K, Psarra AG. Toxics. 2017 Dec 21;6(1).
18.  The Role of S-Palmitoylation of the Human Glucocorticoid Receptor (hGR) in Mediating the Nongenomic Glucocorticoid Actions. Nicolaides NC, Kino T, Roberts ML, Katsantoni E, Sertedaki A, Moutsatsou P, Psarra AG, Chrousos GP, Charmandari E. J Mol Biochem. 2017;6(1):3-12. Epub 2017 Apr 15.
19.  Nanomolar Inhibitors of Glycogen Phosphorylase Based on β-d-Glucosaminyl Heterocycles: A Combined Synthetic, Enzyme Kinetic, and Protein Crystallography Study. Bokor É, Kyriakis E, Solovou TGA, Koppány C, Kantsadi AL, Szabó KE, Szakács A, Stravodimos GA, Docsa T, Skamnaki VT, Zographos SE, Gergely P, Leonidas DD, Somsák L. J Med Chem. 2017 Nov 22;60(22):9251-9262.
20.  Cancer's smart bombs: tumor-derived exosomes target lung epithelial cells triggering pre-metastatic niche formation. Antonopoulos D, Balatsos NAA, Gourgoulianis KI. J Thorac Dis. 2017 Apr;9(4):969-972.
21.  Proteomic Analysis of Human Angiogenin Interactions Reveals Cytoplasmic PCNA as a Putative Binding Partner. Chatzileontiadou DSM, Samiotaki M, Alexopoulou AN, Cotsiki M, Panayotou G, Stamatiadi M, Balatsos NAA, Leonidas DD, Kontou M. J Proteome Res. 2017 Oct 6;16(10):3606-3622.
22.  Marketed drugs used for the management of hypercholesterolemia as anticancer armament. Papanagnou P, Stivarou T, Papageorgiou I, Papadopoulos GE, Pappas A. Onco Targets Ther. 2017 Sep 8;10:4393-4411.
23.  Oxidation of human serum albumin exhibits inter-individual variability after an ultra-marathon mountain race. Spanidis Y, Priftis A, Stagos D, Stravodimos GA, Leonidas DD, Spandidos DA, Tsatsakis AM, Kouretas D. Exp Ther Med. 2017 May;13(5):2382-2390.
24.  van der Waals interactions govern C-β-d-glucopyranosyl triazoles' nM inhibitory potency in human liver glycogen phosphorylase. Kantsadi AL, Stravodimos GA, Kyriakis E, Chatzileontiadou DSM, Solovou TGA, Kun S, Bokor É, Somsák L, Leonidas DD. J Struct Biol. 2017 Jul;199(1):57-67.
25.  Phytogenic Polyphenols as Glycogen Phosphorylase Inhibitors: The Potential of Triterpenes and Flavonoids for Glycaemic Control in Type 2 Diabetes. Stravodimos GA, Chetter BA, Kyriakis E, Kantsadi AL, Chatzileontiadou DS, Skamnaki VT, Kato A, Hayes JM, Leonidas DD. Curr Med Chem. 2017;24(4):384-403.
26.  Evidence for disulfide bonds in SR Protein Kinase 1 (SRPK1) that are required for activity and nuclear localization. Koutroumani M, Papadopoulos GE, Vlassi M, Nikolakaki E, Giannakouros T. PLoS One. 2017 Feb 6;12(2):e0171328.
27.  Frequency Dependent Non- Thermal Effects of Oscillating Electric Fields in the Microwave Region on the Properties of a Solvated Lysozyme System: A Molecular Dynamics Study. Floros S, Liakopoulou-Kyriakides M, Karatasos K, Papadopoulos GE. PLoS One. 2017 Jan 27;12(1):e0169505.
28.  The triterpene echinocystic acid and its 3-O-glucoside derivative are revealed as potent and selective glucocorticoid receptor agonists. Georgatza D, Gorgogietas VA, Kylindri P, Charalambous MC, Papadopoulou KK, Hayes JM, Psarra AG. Int J Biochem Cell Biol. 2016 Oct;79:277-287.
29.  NMR study of Met-1 human Angiogenin: (1)H, (13)C, (15)N backbone and side-chain resonance assignment. Tsika AC, Chatzileontiadou DS, Leonidas DD, Spyroulias GA. Biomol NMR Assign. 2016 Oct;10(2):379-83.
30.  Synthetic, enzyme kinetic, and protein crystallographic studies of C-β-d-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase. Kantsadi AL, Bokor É, Kun S, Stravodimos GA, Chatzileontiadou DSM, Leonidas DD, Juhász-Tóth É, Szakács A, Batta G, Docsa T, Gergely P, Somsák L. Eur J Med Chem. 2016 Nov 10;123:737-745.
31.  The ammonium sulfate inhibition of human angiogenin. Chatzileontiadou DS, Tsirkone VG, Dossi K, Kassouni AG, Liggri PG, Kantsadi AL, Stravodimos GA, Balatsos NA, Skamnaki VT, Leonidas DD. FEBS Lett. 2016 Sep;590(17):3005-18.
32.  Development and Validation of a Kit to Measure Drink Antioxidant Capacity Using a Novel Colorimeter. Priftis A, Stagos D, Tzioumakis N, Konstantinopoulos K, Patouna A, Papadopoulos GE, Tsatsakis A, Kouretas D. Molecules. 2016 Aug 30;21(9).
33.  SNP Identification through Transcriptome Analysis of the European Brown Hare (Lepus europaeus): Cellular Energetics and Mother's Curse. Amoutzias GD, Giannoulis T, Moutou KA, Psarra AM, Stamatis C, Tsipourlianos A, Mamuris Z. PLoS One. 2016 Jul 26;11(7):e0159939.
34.  Chloramphenicol Derivatives as Antibacterial and Anticancer Agents: Historic Problems and Current Solutions. Dinos GP, Athanassopoulos CM, Missiri DA, Giannopoulou PC, Vlachogiannis IA, Papadopoulos GE, Papaioannou D, Kalpaxis DL. Antibiotics (Basel). 2016 Jun 3;5(2). pii: E20.
35.  Preclinical models of atherosclerosis. The future of Hybrid PET/MR technology for the early detection of vulnerable plaque. Cuadrado I, Saura M, Castejón B, Martin AM, Herruzo I, Balatsos N, Zamorano JL, Zaragoza C. Expert Rev Mol Med. 2016 Apr 8;18:e6.
36.  AtHESPERIN: a novel regulator of circadian rhythms with poly(A)-degrading activity in plants. Delis C, Krokida A, Tomatsidou A, Tsikou D, Beta RA, Tsioumpekou M, Moustaka J, Stravodimos G, Leonidas DD, Balatsos NA, Papadopoulou KK. RNA Biol. 2016;13(1):68-82.
37.  Functional characterization of the hGRαT556I causing Chrousos syndrome. Nicolaides NC, Skyrla E, Vlachakis D, Psarra AM, Moutsatsou P, Sertedaki A, Kossida S, Charmandari E. Eur J Clin Invest. 2016 Jan;46(1):42-9.
38.  Triazole double-headed ribonucleosides as inhibitors of eosinophil derived neurotoxin. Chatzileontiadou DS, Parmenopoulou V, Manta S, Kantsadi AL, Kylindri P, Griniezaki M, Kontopoulou F, Telopoulou A, Prokova H, Panagopoulos D, Boix E, Balatsos NA, Komiotis D, Leonidas DD. Bioorg Chem. 2015 Dec;63:152-65.
39.  Detailed study of the dielectric function of a lysozyme solution studied with molecular dynamics simulations.Floros S, Liakopoulou-Kyriakides M, Karatasos K, Papadopoulos GE. Eur Biophys J. 2015 Dec;44(8):599-611.
40.  Poly(A)-specific ribonuclease and Nocturnin in squamous cell lung cancer: prognostic value and impact on gene expression. Maragozidis P, Papanastasi E, Scutelnic D, Totomi A, Kokkori I, Zarogiannis SG, Kerenidi T, Gourgoulianis KI, Balatsos NA. Mol Cancer. 2015 Nov 5;14:187.
41.  An evaluation of indirubin analogues as phosphorylase kinase inhibitors. Begum J, Skamnaki VT, Moffatt C, Bischler N, Sarrou J, Skaltsounis AL, Leonidas DD, Oikonomakos NG, Hayes JM. J Mol Graph Model. 2015 Sep;61:231-42.
42.  Synthesis and evaluation of chloramphenicol homodimers: molecular target, antimicrobial activity, and toxicity against human cells. Kostopoulou ON, Magoulas GE, Papadopoulos GE, Mouzaki A, Dinos GP, Papaioannou D, Kalpaxis DL. PLoS One. 2015 Aug 12;10(8):e0134526.
43.  Glycogen phosphorylase as a target for type 2 diabetes: synthetic, biochemical, structural and computational evaluation of novel N-acyl-N´-(β-D-glucopyranosyl) urea inhibitors. Kantsadi AL, Parmenopoulou V, Bakalov DN, Snelgrove L, Stravodimos GA, Chatzileontiadou DS, Manta S, Panagiotopoulou A, Hayes JM, Komiotis D, Leonidas DD. Curr Top Med Chem. 2015;15(23):2373-89.
44.  Molecular Cloning, Carbohydrate Specificity and the Crystal Structure of Two Sclerotium rolfsii Lectin Variants. Peppa VI, Venkat H, Kantsadi AL, Inamdar SR, Bhat GG, Eligar S, Shivanand A, Chachadi VB, Satisha GJ, Swamy BM, Skamnaki VT, Zographos SE, Leonidas DD. Molecules. 2015 Jun 12;20(6):10848-65.
45.  A novel mutation of the hGR gene causing Chrousos syndrome. Nicolaides NC, Geer EB, Vlachakis D, Roberts ML, Psarra AM, Moutsatsou P, Sertedaki A, Kossida S, Charmandari E. Eur J Clin Invest. 2015 Aug;45(8):782-91.
46.  Structural properties and interaction energies affecting drug design. An approach combining molecular simulations, statistics, interaction energies and neural networks. Ioannidis D, Papadopoulos GE, Anastassopoulos G, Kortsaris A, Anagnostopoulos K. Comput Biol Chem. 2015 Jun;56:7-12.
47.  Natural flavonoids as antidiabetic agents. The binding of gallic and ellagic acids to glycogen phosphorylase b. Kyriakis E, Stravodimos GA, Kantsadi AL, Chatzileontiadou DS, Skamnaki VT, Leonidas DD. FEBS Lett. 2015 Jul 8;589(15):1787-94.
48.  Correlation between Central Corneal Thickness and Intraocular Pressure Measured by Goldmann Applanation Tonometry or Pascal Dynamic Contour Tonometry. Katsimpris JM, Theoulakis PE, Vasilopoulos K, Skourtis G, Papadopoulos GE, Petropoulos IK. Klin Monbl Augenheilkd. 2015 Apr;232(4):414-8.
6. Thesis:

Ph.D. Theses
  1. Giannouli Stamatina: «Genomic and functional analysis of non-conventional aminoacylation systems in pathogens» (Supervisor: K. Stathopoulos)

  2.  Karoulia Zoi: «A functional and structural study of the von Willebrand factor and its role in hemostasis individual reactions» (Supervisor: D.D. Leonidas)

  3. Kantsadi Anastasia: «Glycogen phosphorylase as a molecular target for the design of new antihyperglycaemic drugs» (Supervisor: D.D. Leonidas)

  4.   Chatzileontiadou Dimitra: «Biochemical studies on human angiogenin» (Supervisor: D.D. Leonidas)

  5.   Gorgogietas Vyronas: «Role of steroid hormone receptors in the regulation of cellular pathophysiology» (Supervisor: Α.-Μ Psarra)

  6.  Stravodimos Georgios: «Biochemical studies of enzymes in glycogen metabolism» (Supervisor: D.D. Leonidas)

  7. Floros Stelios: «Study the behavior of proteins in alternating electric field in molecular dynamics simulations (in progress» (Co-Supervior: G. Papadopoulos)


 
7. Lab equipment:
 
·X-ray source Microstar Bruker Rotating Anode equipped with a MAR345 Image Plate detector and Oxford Cryostream

· Fast Protein Liquid Chromatography (ÄKTA purifier UPC-900 – FPLC system – GE Healthcare Life Sciences)

· Fluorescent microscopy (Leica – DM 200)

· Confocal microscopy (Zeiss – LSM800)

· Tube Luminometer (Berthold Technologies –Lumat3- LB 9508)

· Protein Crystallization Robot (Robot OryxNano –Douglas Instruments Ltd)

· Spectometry (UV-1600 PC Spectrophotometer – VWR)

· Vertical Laminar Flow Bench –mammalian cell culture (AV-30/70 – TELSTAR)

· Incubator CO2 37οC - mammalian cell culture (Galaxy 170S – New Brunswick)

· Incubator CO2 37οC –mammalian cell culture (3111 - Thermo electron Corporation)

· Cooler incubator – cell culture for bacterial (Labtech)

· pH-meter (Metrohm)

· Centrifuge (Eppendorf Centrifuge 5810R, HermLe Z36HK, HITACHI CR22N)

· Gel imaging system (Bio-rad)

· Stereoscope microscope (Olympus TL2)

· Real-Time PCR (Bio-rad)

· PCR (Eppendorf)

 
 
8. Useful Links:
9. Photos:
 
   

 
 
 
 10.Contact:

Professor Demetres D. Leonidas
Department of Biochemistry and Biotechnology
University of Thessaly
Viopolis 
41500  Larissa
Tel. 2410-565278
Fax. 2410-565290
Email.  This e-mail address is being protected from spambots. You need JavaScript enabled to view it

Assistant Professor M. Kontou
Department of Biochemistry and Biotechnology
University of Thessaly
Viopolis
41500 Larissa
Tel. 2410-565281
Fax. 2410-565290
Email.  This e-mail address is being protected from spambots. You need JavaScript enabled to view it

Assistant Professor N. Balatsos
Department of Biochemistry and Biotechnology
University of Thessaly
Viopolis
41500 Larissa
Τel. 2410-565261
Fax. 2410-565290
Email.  This e-mail address is being protected from spambots. You need JavaScript enabled to view it

Assistant Professor G. Papadopoulos
Department of Biochemistry and Biotechnology
University of Thessaly
Viopolis 
41500 Larissa
Τel. 2410-565249
Fax. 2410-565290
Email.  This e-mail address is being protected from spambots. You need JavaScript enabled to view it

Assistant Professor Α.-Μ. Psarra
Department of Biochemistry and Biotechnology
University of Thessaly
Viopolis
41500 Larissa
Τel. 2410-565221
Fax. 2410-565290
Email.  This e-mail address is being protected from spambots. You need JavaScript enabled to view it

Assistant Professor V. Skamnaki
Department of Biochemistry and Biotechnology
University of Thessaly
Viopolis
41500 Larissa
Τel. 2410-565267
Fax. 2410-565290
Email:  This e-mail address is being protected from spambots. You need JavaScript enabled to view it

Special Teaching Staff Sotirios Marras
Department of Biochemistry and Biotechnology
University of Thessaly
Viopolis
41500 Larissa
Τel. 2410-565267
Fax. 2410-565290
 
 

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